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Volume 9, Issue 2 (Spring 2023)
Caspian J Neurol Sci 2023, 9(2): 92-101 |
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Maleknejad S, Farzi F, Heidarzadeh A, Safaei Asl A, Hasanzadeh Rad A, Hoseini Nouri S A. Oral Ketamine or Nasal Midazolam for Sedation in Pediatric Upper Gastrointestinal Endoscopy. Caspian J Neurol Sci 2023; 9 (2) :92-101
URL: http://cjns.gums.ac.ir/article-1-618-en.html
URL: http://cjns.gums.ac.ir/article-1-618-en.html
Shohreh Maleknejad * 
1, Farnoush Farzi2 , Abtin Heidarzadeh3 , Afshin Safaei Asl1 , Afagh Hasanzadeh Rad1 , Seyyedeh Azade Hoseini Nouri1
1, Farnoush Farzi2 , Abtin Heidarzadeh3 , Afshin Safaei Asl1 , Afagh Hasanzadeh Rad1 , Seyyedeh Azade Hoseini Nouri1
1- Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
3- Medical Education Research Center, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
3- Medical Education Research Center, Guilan University of Medical Sciences, Rasht, Iran
Abstract: (563 Views)
Background: There is no agreement on the route of administration and the drug of choice for providing adequate sedation for pediatric invasive procedures.
Objectives: We compared the utility, safety, and sedation effects of intranasal midazolam and oral ketamine.
Materials & Methods: This double-blind clinical trial was performed on 100 children aged 2 to 14 years who were candidates for upper gastrointestinal (GI) endoscopy. Patients were randomly assigned to two groups: ketamine (4 mg/kg orally) and midazolam (0.1 mg/ kg intranasal). Sedation score, fear levels, children’s behavior at the time of separation from parents, and vital signs were recorded.
Results: Higher systolic blood pressure was seen in children who received ketamine (P=0.012) and lower arterial oxygen saturation in the midazolam group (P=0.023). Also, the level of sedation showed no significant difference between the groups.
Conclusion: Based on the results, administering oral ketamine or intranasal midazolam before endoscopy induced a similar sedation score in children. Also, both methods could be safe and non-invasive modalities for sedation.
Objectives: We compared the utility, safety, and sedation effects of intranasal midazolam and oral ketamine.
Materials & Methods: This double-blind clinical trial was performed on 100 children aged 2 to 14 years who were candidates for upper gastrointestinal (GI) endoscopy. Patients were randomly assigned to two groups: ketamine (4 mg/kg orally) and midazolam (0.1 mg/ kg intranasal). Sedation score, fear levels, children’s behavior at the time of separation from parents, and vital signs were recorded.
Results: Higher systolic blood pressure was seen in children who received ketamine (P=0.012) and lower arterial oxygen saturation in the midazolam group (P=0.023). Also, the level of sedation showed no significant difference between the groups.
Conclusion: Based on the results, administering oral ketamine or intranasal midazolam before endoscopy induced a similar sedation score in children. Also, both methods could be safe and non-invasive modalities for sedation.
Type of Study: Research |
Subject:
Special
Received: 2023/03/28 | Accepted: 2023/01/11 | Published: 2023/04/23
Received: 2023/03/28 | Accepted: 2023/01/11 | Published: 2023/04/23
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