Mon, Feb 16, 2026
Volume 12, Issue 1 (Winter 2026 2026)
Caspian J Neurol Sci 2026, 12(1): 41-50 |
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Rahadi D A, Pratama M I, Abdillah T M. Fibrinogen as a Predictor of Depression and Cognitive Impairment After Ischemic Stroke: A Meta-analysis. Caspian J Neurol Sci 2026; 12 (1) :41-50
URL: http://cjns.gums.ac.ir/article-1-803-en.html
URL: http://cjns.gums.ac.ir/article-1-803-en.html
1- Biomedical Master Program, Faculty of Medicine, Universitas Andalas, Padang, Indonesia , didan.rohadi@gmail.com
2- Department of Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
2- Department of Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Abstract: (29 Views)
Background: Acute ischemic stroke (AIS) is related to higher disability. Post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI) are the two conditions, which significantly impact patient recovery and quality of life (QoL). Fibrinogen, an acute-phase protein, is elevated during AIS, and has been implicated in various neurological disorders.
Objectives: We assessed the association between higher fibrinogen levels and the risk of PSD and PSCI in AIS patients.
Materials & Methods: We conducted a meta-analysis of studies published up to June 2025 across three databases, including PubMed, ScienceDirect, and Web of Science. Eligible studies assessed the association between fibrinogen and PSD and PSCI among AIS patients.
Results: Our study included nine observational studies conducted in China, with a total sample size of 3.328 patients. The meta-analysis consistently demonstrated a significant positive association between elevated fibrinogen levels and an increased risk of both PSD and PSCI. For PSD, the adjusted odds ratio (aOR) across five studies was 1.43 (95% CI, 1.3%, 1.5%; P<0.00001). For PSCI, aOR from three studies was 1.59 (95% CI, 1.19%, 2.11%; P=0.002). These associations largely persisted after adjustment for various confounding factors. All included studies were conducted in China and predominantly involved male patients.
Conclusion: Elevated fibrinogen on admission was statistically positively correlated with an increased risk of PSD and PSCI incidence. Fibrinogen is a valuable prognostic biomarker for early stratification of patients with a high risk of developing neuropsychiatric complications after AIS.
Objectives: We assessed the association between higher fibrinogen levels and the risk of PSD and PSCI in AIS patients.
Materials & Methods: We conducted a meta-analysis of studies published up to June 2025 across three databases, including PubMed, ScienceDirect, and Web of Science. Eligible studies assessed the association between fibrinogen and PSD and PSCI among AIS patients.
Results: Our study included nine observational studies conducted in China, with a total sample size of 3.328 patients. The meta-analysis consistently demonstrated a significant positive association between elevated fibrinogen levels and an increased risk of both PSD and PSCI. For PSD, the adjusted odds ratio (aOR) across five studies was 1.43 (95% CI, 1.3%, 1.5%; P<0.00001). For PSCI, aOR from three studies was 1.59 (95% CI, 1.19%, 2.11%; P=0.002). These associations largely persisted after adjustment for various confounding factors. All included studies were conducted in China and predominantly involved male patients.
Conclusion: Elevated fibrinogen on admission was statistically positively correlated with an increased risk of PSD and PSCI incidence. Fibrinogen is a valuable prognostic biomarker for early stratification of patients with a high risk of developing neuropsychiatric complications after AIS.
Type of Study: Research |
Subject:
General
Received: 2025/08/17 | Accepted: 2025/11/17 | Published: 2026/01/11
Received: 2025/08/17 | Accepted: 2025/11/17 | Published: 2026/01/11
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