Fri, Oct 31, 2025
Volume 11, Issue 1 (Winter 2025)
Caspian J Neurol Sci 2025, 11(1): 17-27 |
Back to browse issues page
Ethics code: IR.GUMS.REC.1401.380
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
AmirAshjei Asalemi K, Saberi A, Ghayeghran A, Fallah Arzpeyma S, Eskandarieh S, Sahraian M A, et al . Clinical and Imaging Features of Familial and Sporadic Multiple Sclerosis. Caspian J Neurol Sci 2025; 11 (1) :17-27
URL: http://cjns.gums.ac.ir/article-1-748-en.html
URL: http://cjns.gums.ac.ir/article-1-748-en.html
Kamal AmirAshjei Asalemi1 
, Alia Saberi2 , Amirreza Ghayeghran2 , Sima Fallah Arzpeyma3 , Sharareh Eskandarieh4 , Mohammad Ali Sahraian4 , Hamidreza Hatamian2 , Kasra Sarlak1 , Negin Ashoori5 , Nima Broomand Lomer *6
, Alia Saberi2 , Amirreza Ghayeghran2 , Sima Fallah Arzpeyma3 , Sharareh Eskandarieh4 , Mohammad Ali Sahraian4 , Hamidreza Hatamian2 , Kasra Sarlak1 , Negin Ashoori5 , Nima Broomand Lomer *6
1- Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
4- Neuroscience Institute, Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Neurology, Faculty of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
6- Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. ,nima.broomand@gmail.com
2- Neurosciences Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
4- Neuroscience Institute, Multiple Sclerosis Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Neurology, Faculty of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
6- Department of Neurology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (818 Views)
Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease affecting the central nervous system (CNS). While most cases are sporadic, familial MS (FMS) constitutes approximately 12.6% of the MS population and is characterized by affected family members. This study aims to investigate the difference between clinical and radiological findings of patients with FMS and sporadic MS (SMS) living in Guilan Province, Iran.
Materials & Methods: In this cross-sectional study, by evaluating their medical records, we examined 113 patients with SMS and 79 patients with FMS who registered in the nationwide MS registry of Iran (NMSRI)-Guilan. The radiologic data were analyzed using OsiriX software, version 12.0.
Results: Compared to the FMS group, the SMS group showed significantly higher age at onset (31.48±9.55 vs 28.92±9.46, P=0.034), higher occurrence of diplopia (29.2% vs 16.4%, P=0.042), higher expanded disability status scale (EDSS) score (2.20±2.61 vs 1.09±2.08, P=0.002), more lesions (31.59±25.36 vs 22.83±17.17, P=0.017), higher frequency of lesions in the periventricular region (98.2% vs 89.8%, P=0.017) and the lower average size of the smallest lesions (4.65±2.57 vs 8.12±8.58, P<0.001). EDSS score showed significant associations with type of MS (SMS or FMS) (β=0.78, P=0.016), onset age (β=0.09, P<0.001) and disease duration (β=0.13, P=0.001).
Conclusion: FMS differs from SMS with an earlier onset, predominantly relapsing-remitting phenotype, lower diplopia incidence, lower EDSS scores, fewer periventricular lesions and larger smallest lesions.
Materials & Methods: In this cross-sectional study, by evaluating their medical records, we examined 113 patients with SMS and 79 patients with FMS who registered in the nationwide MS registry of Iran (NMSRI)-Guilan. The radiologic data were analyzed using OsiriX software, version 12.0.
Results: Compared to the FMS group, the SMS group showed significantly higher age at onset (31.48±9.55 vs 28.92±9.46, P=0.034), higher occurrence of diplopia (29.2% vs 16.4%, P=0.042), higher expanded disability status scale (EDSS) score (2.20±2.61 vs 1.09±2.08, P=0.002), more lesions (31.59±25.36 vs 22.83±17.17, P=0.017), higher frequency of lesions in the periventricular region (98.2% vs 89.8%, P=0.017) and the lower average size of the smallest lesions (4.65±2.57 vs 8.12±8.58, P<0.001). EDSS score showed significant associations with type of MS (SMS or FMS) (β=0.78, P=0.016), onset age (β=0.09, P<0.001) and disease duration (β=0.13, P=0.001).
Conclusion: FMS differs from SMS with an earlier onset, predominantly relapsing-remitting phenotype, lower diplopia incidence, lower EDSS scores, fewer periventricular lesions and larger smallest lesions.
Keywords: Multiple sclerosis, Magnetic resonance imaging, Relapsing-Remitting, Disability evaluation
Type of Study: Research |
Subject:
Special
Received: 2024/05/17 | Accepted: 2024/06/18 | Published: 2025/01/1
Received: 2024/05/17 | Accepted: 2024/06/18 | Published: 2025/01/1
Send email to the article author
| Rights and permissions | |
 | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright © The Author(s);
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
