Mon, Sep 29, 2025
Volume 10, Issue 4 (Autumn 2024)
Caspian J Neurol Sci 2024, 10(4): 341-346 |
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Sedighinejad A, Zavarmousavi S M, Soltanipour S, Naderi Nabi B, Safari moghadam F, Shahrokhi Rad R et al . The Impact of Delivery Mode on the Development of Behavioral Disorders in Children. Caspian J Neurol Sci 2024; 10 (4) :341-346
URL: http://cjns.gums.ac.ir/article-1-731-en.html
URL: http://cjns.gums.ac.ir/article-1-731-en.html
Abbas Sedighinejad1 
, Seyedeh Maryam Zavarmousavi2 , Soheil Soltanipour3 , Bahram Naderi Nabi1 , Fatemeh Safari moghadam4 , Reyhaneh Shahrokhi Rad *5 , Gelareh Biazar1
, Seyedeh Maryam Zavarmousavi2 , Soheil Soltanipour3 , Bahram Naderi Nabi1 , Fatemeh Safari moghadam4 , Reyhaneh Shahrokhi Rad *5 , Gelareh Biazar1
1- Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
2- Department of Psychiatry, School of Medicine, Kavosh Cognitive Behavior Sciences and Addiction Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
4- Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
5- Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran. ,shahrokhireyhaneh@yahoo.com
2- Department of Psychiatry, School of Medicine, Kavosh Cognitive Behavior Sciences and Addiction Research Center, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
4- Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
5- Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (630 Views)
Background: Existing evidence on the relationship between mode of delivery and offspring’s emotional and behavioral problems is limited and inconsistent.
Objectives: This study investigated the relationship between anesthesia during childbirth and behavioral disorders in children.
Materials & Methods: This research was conducted at psychiatric clinics affiliated with Guilan University of Medical Sciences (GUMS), Rasht City, Iran. The studied population consisted of children who were diagnosed with autism spectrum disorder, attention-deficit/hyperactivity disorder, and oppositional defiant disorder based on DSM-5 criteria. For each case, a healthy sibling was considered as a control group. We completed a checklist containing the type of delivery, including normal vaginal delivery (NVD), cesarean section (CS) under general anesthesia (GA) or spinal anesthesia (SA), and painless labor, as well as neonate birth status (term/preterm).
Results: In this study, 720 children aged 4-18 were enrolled. No significant difference was observed in terms of birth status (term or preterm) (P=0.482), age (P=0.464), and mode of delivery (P=0.236), while the difference was significant regarding gender (P=0.001) and type of anesthesia (P=0.0001). So, delivery under GA was significantly associated with behavioral disorders compared to NVD or CS under SA (P=0.0001). The logistic regression test demonstrated that CS under GA increases 2.74 times the likelihood of later development of behavioral disorders.
Conclusion: Children born by elective CS under GA may face childhood behavioral problems. Further investigation is needed to support these findings in other populations and explore the potential biological mechanisms.
Objectives: This study investigated the relationship between anesthesia during childbirth and behavioral disorders in children.
Materials & Methods: This research was conducted at psychiatric clinics affiliated with Guilan University of Medical Sciences (GUMS), Rasht City, Iran. The studied population consisted of children who were diagnosed with autism spectrum disorder, attention-deficit/hyperactivity disorder, and oppositional defiant disorder based on DSM-5 criteria. For each case, a healthy sibling was considered as a control group. We completed a checklist containing the type of delivery, including normal vaginal delivery (NVD), cesarean section (CS) under general anesthesia (GA) or spinal anesthesia (SA), and painless labor, as well as neonate birth status (term/preterm).
Results: In this study, 720 children aged 4-18 were enrolled. No significant difference was observed in terms of birth status (term or preterm) (P=0.482), age (P=0.464), and mode of delivery (P=0.236), while the difference was significant regarding gender (P=0.001) and type of anesthesia (P=0.0001). So, delivery under GA was significantly associated with behavioral disorders compared to NVD or CS under SA (P=0.0001). The logistic regression test demonstrated that CS under GA increases 2.74 times the likelihood of later development of behavioral disorders.
Conclusion: Children born by elective CS under GA may face childhood behavioral problems. Further investigation is needed to support these findings in other populations and explore the potential biological mechanisms.
Type of Study: Research |
Subject:
Special
Received: 2024/07/24 | Accepted: 2024/09/28 | Published: 2024/10/1
Received: 2024/07/24 | Accepted: 2024/09/28 | Published: 2024/10/1
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