Sat, May 18, 2024
Volume 10, Issue 1 (Winter 2024)
Caspian J Neurol Sci 2024, 10(1): 57-67 |
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Nosratiyan M, Farjah G H, Saberi H. The Effect of Low-intensity Remote Ultrasound on Sciatic Nerve Regeneration in Male Rats. Caspian J Neurol Sci 2024; 10 (1) :57-67
URL: http://cjns.gums.ac.ir/article-1-691-en.html
URL: http://cjns.gums.ac.ir/article-1-691-en.html
1- Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
2- Department of Anatomy, Neurophysiology Research Center, School of Medicine, Cellular and Molecular Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
3- Department of Medical Physics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
2- Department of Anatomy, Neurophysiology Research Center, School of Medicine, Cellular and Molecular Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
3- Department of Medical Physics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Abstract: (178 Views)
Background: Ultrasonic therapy is used locally to repair damaged peripheral nerves.
Objectives: This study was designed to examine the effect of low-intensity remote ultrasound on peripheral nerve regeneration.
Materials & Methods: In the present study, 24 male rats were randomly divided into three groups: Sham surgery (SS: No sciatic crush injury, no ultrasonic treatment, n=8), control (C: Sciatic crush injury, without ultrasonic treatment, n=8), and remote ultrasound (RU: Sciatic crush injury, ultrasonic treatment, n=8). To induce nerve crush, the sciatic nerve was clamped 1 cm above the bifurcation site for 30 seconds. In the RU group, the opposite leg was treated with low-intensity ultrasound for 10 minutes, 3 times a week for 4 weeks (1.1 MHz frequency with an intensity of 0.5 W/cm2). Neurological evaluation was done by examining the sciatic nerve index (SFI) on days 7, 21, 28, 35, 49, and 56 after surgery. The samples were evaluated histologically, biochemically, and immunohistologically on days 28 and 56 after surgery.
Results: The mean SFI, transverse diameter of muscle fibers, and the number of myelinated axons in the RU group were higher than those in the control group (P<0.05). Also, the mean plasma levels of total antioxidant capacity, malondialdehyde, interleukin-6, and HSP70 in the control group differed from the RU group on days 28 and 56 after surgery (P<0.05).
Conclusion: The results of the present study show that low-intensity remote ultrasound has beneficial effects on the crushed sciatic nerve.
Objectives: This study was designed to examine the effect of low-intensity remote ultrasound on peripheral nerve regeneration.
Materials & Methods: In the present study, 24 male rats were randomly divided into three groups: Sham surgery (SS: No sciatic crush injury, no ultrasonic treatment, n=8), control (C: Sciatic crush injury, without ultrasonic treatment, n=8), and remote ultrasound (RU: Sciatic crush injury, ultrasonic treatment, n=8). To induce nerve crush, the sciatic nerve was clamped 1 cm above the bifurcation site for 30 seconds. In the RU group, the opposite leg was treated with low-intensity ultrasound for 10 minutes, 3 times a week for 4 weeks (1.1 MHz frequency with an intensity of 0.5 W/cm2). Neurological evaluation was done by examining the sciatic nerve index (SFI) on days 7, 21, 28, 35, 49, and 56 after surgery. The samples were evaluated histologically, biochemically, and immunohistologically on days 28 and 56 after surgery.
Results: The mean SFI, transverse diameter of muscle fibers, and the number of myelinated axons in the RU group were higher than those in the control group (P<0.05). Also, the mean plasma levels of total antioxidant capacity, malondialdehyde, interleukin-6, and HSP70 in the control group differed from the RU group on days 28 and 56 after surgery (P<0.05).
Conclusion: The results of the present study show that low-intensity remote ultrasound has beneficial effects on the crushed sciatic nerve.
Type of Study: Research |
Subject:
Special
Received: 2024/01/28 | Accepted: 2024/01/20 | Published: 2024/01/20
Received: 2024/01/28 | Accepted: 2024/01/20 | Published: 2024/01/20
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Articles Copyright © The Author(s).
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information
Caspian Journal of Neurological Sciences
Guilan University of Medical Sciences
University Tel : +9813 3333 0939
E-mail: cjnsgums@gmail.com, cjns@gums.ac.ir
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information
Caspian Journal of Neurological Sciences
Guilan University of Medical Sciences
University Tel : +9813 3333 0939
E-mail: cjnsgums@gmail.com, cjns@gums.ac.ir
