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Volume 9, Issue 4 (Autumn 2023)
Caspian J Neurol Sci 2023, 9(4): 201-209 |
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Keymoradzadeh A, Saberi A, Soleymanpour A, Roshan A, Mohammadi P, Bakhshi A. Systemic Inflammation Biomarkers Ratio as Predictors of Clinical Outcomes in Ischemic Stroke. Caspian J Neurol Sci 2023; 9 (4) :201-209
URL: http://cjns.gums.ac.ir/article-1-662-en.html
URL: http://cjns.gums.ac.ir/article-1-662-en.html
Arman Keymoradzadeh *1 
, Alia Saberi2 , Armin Soleymanpour3 , Amirhossein Roshan3 , Parastoo Mohammadi3 , Arash Bakhshi3
, Alia Saberi2 , Armin Soleymanpour3 , Amirhossein Roshan3 , Parastoo Mohammadi3 , Arash Bakhshi3
1- Department of Neurosurgery, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Neurology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
3- Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Iran
2- Department of Neurology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
3- Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Iran
Abstract: (1217 Views)
Background: Strokes are among the major causes of disabilities worldwide. In recent years, there
has been considerable interest in evaluating stroke prognoses.
Objectives: In this investigation, we studied the association of lymphocyte-monocyte ratio (LMR),
neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP),
erythrocyte sedimentation rate (ESR) and ESR-CRP ratio (ECR) with 3 months outcomes among
those with acute ischemic stroke (AIS).
Materials & Methods: We carried out the present cross-sectional investigation among AIS patients
at an academic hospital in northern Iran (from 2019 to 2021). Within 24 hours after the onset of
symptoms, laboratory and clinical data of the patients were obtained. We assessed the results using
the modified rankin scale (mRS) 90 days after the initial assessment. Statistical significance for
comparing descriptive data was determined as P<0.05.
Results: We entered 341 participants (Mean±SD age: 69.10±13.55 years, 53.1% female) into this
investigation. Based on univariate analysis, there were poor correlations between NLR (r=0.361, P<0.001),
PLR (r=0.215, P<0.05), CRP (r=0.234, P<0.001), LMR (r=-0.184, P<0.05), and ECR (r=-0.191, P<0.05)
and a 3-month mRS. Also, after three months, the NLR, PLR, and CRP values were higher in the patients
who died, but the LMR (P<0.001) and ECR (P<0.05) were lower. In multivariate comparison, only ECR was
independently higher among the participants who died within 3 months (P<0.05).
Conclusion: In this study, ECR within 24 hours of symptoms onset was related to functional
outcomes and mortality at 3-month follow-up. Thus, ECR might provide valuable prognostic
information at a relatively low cost.
has been considerable interest in evaluating stroke prognoses.
Objectives: In this investigation, we studied the association of lymphocyte-monocyte ratio (LMR),
neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP),
erythrocyte sedimentation rate (ESR) and ESR-CRP ratio (ECR) with 3 months outcomes among
those with acute ischemic stroke (AIS).
Materials & Methods: We carried out the present cross-sectional investigation among AIS patients
at an academic hospital in northern Iran (from 2019 to 2021). Within 24 hours after the onset of
symptoms, laboratory and clinical data of the patients were obtained. We assessed the results using
the modified rankin scale (mRS) 90 days after the initial assessment. Statistical significance for
comparing descriptive data was determined as P<0.05.
Results: We entered 341 participants (Mean±SD age: 69.10±13.55 years, 53.1% female) into this
investigation. Based on univariate analysis, there were poor correlations between NLR (r=0.361, P<0.001),
PLR (r=0.215, P<0.05), CRP (r=0.234, P<0.001), LMR (r=-0.184, P<0.05), and ECR (r=-0.191, P<0.05)
and a 3-month mRS. Also, after three months, the NLR, PLR, and CRP values were higher in the patients
who died, but the LMR (P<0.001) and ECR (P<0.05) were lower. In multivariate comparison, only ECR was
independently higher among the participants who died within 3 months (P<0.05).
Conclusion: In this study, ECR within 24 hours of symptoms onset was related to functional
outcomes and mortality at 3-month follow-up. Thus, ECR might provide valuable prognostic
information at a relatively low cost.
Keywords: Ischemic stroke, Patient outcomes assessment, Leukocyte counts, C-reactive protein, Blood sedimentation
Type of Study: Research |
Subject:
Special
Received: 2023/10/11 | Accepted: 2023/10/17 | Published: 2023/10/17
Received: 2023/10/11 | Accepted: 2023/10/17 | Published: 2023/10/17
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