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Volume 9, Issue 2 (Spring 2023)
Caspian J Neurol Sci 2023, 9(2): 102-107 |
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Joukar F, Asgharnezhad M, Faraji N, Zeinali T, Hojati A, Maveddati S, et al . The Association Between Depression and Activity of Inflammatory Bowel Disease. Caspian J Neurol Sci 2023; 9 (2) :102-107
URL: http://cjns.gums.ac.ir/article-1-615-en.html
URL: http://cjns.gums.ac.ir/article-1-615-en.html
Farahnaz Joukar * 
1, Mehrnaz Asgharnezhad1 , Niloofar Faraji1 , Tahereh Zeinali1 , Amineh Hojati1 , Sara Maveddati2 , Masood Sepehrimanesh3 , Adeleh Isanazar4 , Alireza Mansour-Ghanaei1 , Alireza Samadi1 , Fariborz Mansour-Ghanaei1
1, Mehrnaz Asgharnezhad1 , Niloofar Faraji1 , Tahereh Zeinali1 , Amineh Hojati1 , Sara Maveddati2 , Masood Sepehrimanesh3 , Adeleh Isanazar4 , Alireza Mansour-Ghanaei1 , Alireza Samadi1 , Fariborz Mansour-Ghanaei1
1- Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Medicine, Universita Degli Studi di Bari Aldo Moro, Bari, Italy
3- Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, United States
4- Department of Psychiatry, School of Medicine, Shafa Hospital, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Medicine, Universita Degli Studi di Bari Aldo Moro, Bari, Italy
3- Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, United States
4- Department of Psychiatry, School of Medicine, Shafa Hospital, Guilan University of Medical Sciences, Rasht, Iran
Abstract: (539 Views)
Background: The association between depression and inflammatory bowel disease (IBD) has been reported worldwide.
Objectives: We aimed to investigate the prevalence of active and inactive IBD depression and its associated risk factors among patients with depression and IBD.
Materials & Methods: In this cross-sectional study, demographic data and clinical characteristics of 156 IBD patients referred to Razi Hospital, Rasht City, Iran, were recorded from 2015 to 2016. The Beck depression inventory (BDI) was administered to all patients, and their scores were classified as no, mild, moderate, and severe depression. Modified Truelove and Witts severity index (MTWSI) for ulcerative colitis (UC) and Harvey Bradshaw severity index (HBSI) for Crohn’s disease (CD) were used to quantitate IBD activity as active UC (scored ≥10) and active CD (scored ≥7).
Results: About 35.9% of the patients (n=56) had depression. Patients with active IBD had significantly higher BDI scores than those with inactive IBD (14.41±10.34 vs 10.14±10.28, respectively, P=0.011). Except for income (P=0.001), no significant associations were detected between IBD status and other background variables (P>0.05). No patients in either active or inactive IBD groups had cancers. Based on the severity of depression, the patients were grouped as follows: 64.1% had no depression, 30.1% had mild depression, 5.8% had moderate depression, and 0.0% had severe depression. However, significant positive associations were seen between an increase in depression severity and having autoimmune diseases, a lower education level, and a history of IBD-related surgeries.
Conclusion: It seems that patients with active IBD are more depressed than inactive IBD patients.
Objectives: We aimed to investigate the prevalence of active and inactive IBD depression and its associated risk factors among patients with depression and IBD.
Materials & Methods: In this cross-sectional study, demographic data and clinical characteristics of 156 IBD patients referred to Razi Hospital, Rasht City, Iran, were recorded from 2015 to 2016. The Beck depression inventory (BDI) was administered to all patients, and their scores were classified as no, mild, moderate, and severe depression. Modified Truelove and Witts severity index (MTWSI) for ulcerative colitis (UC) and Harvey Bradshaw severity index (HBSI) for Crohn’s disease (CD) were used to quantitate IBD activity as active UC (scored ≥10) and active CD (scored ≥7).
Results: About 35.9% of the patients (n=56) had depression. Patients with active IBD had significantly higher BDI scores than those with inactive IBD (14.41±10.34 vs 10.14±10.28, respectively, P=0.011). Except for income (P=0.001), no significant associations were detected between IBD status and other background variables (P>0.05). No patients in either active or inactive IBD groups had cancers. Based on the severity of depression, the patients were grouped as follows: 64.1% had no depression, 30.1% had mild depression, 5.8% had moderate depression, and 0.0% had severe depression. However, significant positive associations were seen between an increase in depression severity and having autoimmune diseases, a lower education level, and a history of IBD-related surgeries.
Conclusion: It seems that patients with active IBD are more depressed than inactive IBD patients.
Type of Study: Research |
Subject:
Special
Received: 2023/03/28 | Accepted: 2023/01/11 | Published: 2023/04/23
Received: 2023/03/28 | Accepted: 2023/01/11 | Published: 2023/04/23
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Articles Copyright © The Author(s).
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information
Caspian Journal of Neurological Sciences
Guilan University of Medical Sciences
University Tel : +9813 3333 0939
E-mail: cjnsgums@gmail.com, cjns@gums.ac.ir
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information
Caspian Journal of Neurological Sciences
Guilan University of Medical Sciences
University Tel : +9813 3333 0939
E-mail: cjnsgums@gmail.com, cjns@gums.ac.ir
