Anti-N-Methyl-D-Aspartate-Receptor Encephalitis, a Challenge for Neurologists or a Chameleon for Psychiatrists: A Case Report

Ghabeli-Juibary , Ali; Rezaei-Ardani , Amir; Rezaeitalab , Fariborz; Verdipoor , Mahdieh

doi:10.18869/acadpub.cjns.1.2.52

Volume 1, Issue 2 (Summer 2015) Caspian J Neurol Sci 2015, 1(2): 52-55 | Back to browse issues page

‎ 10.18869/acadpub.cjns.1.2.52

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Ghabeli-Juibary A, Rezaei-Ardani A, Rezaeitalab F, Verdipoor M. Anti-N-Methyl-D-Aspartate-Receptor Encephalitis, a Challenge for Neurologists or a Chameleon for Psychiatrists: A Case Report. Caspian J Neurol Sci 2015; 1 (2) :52-55
URL: http://cjns.gums.ac.ir/article-1-53-en.html

Anti-N-Methyl-D-Aspartate-Receptor Encephalitis, a Challenge for Neurologists or a Chameleon for Psychiatrists: A Case Report

Ali Ghabeli-Juibary¹

, Amir Rezaei-Ardani²

, Fariborz Rezaeitalab ^*

³, Mahdieh Verdipoor¹

1- Resident of Neurology, Department of Neurology, Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Assistant professor of psychiatry, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3- Assistant professor of Neurology, Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ; rezaeitalabf@mums.ac.ir

Abstract: (5353 Views)

Anti-N-Methyl-D-Aspartate-Receptor (NMDA-R) encephalitis is a new autoimmune disorder, often paraneoplastic in nature, presenting with complex neuropsychiatric symptoms. Diagnosed serologically, this disorder is often responsive to immunosuppressant treatment. We here in report the case of a 56-year-old man with anti NMDA-R encephalitis presenting initially with disorientation and hallucination. He later developed bilateral ophthalmoplegia and spastic tetraparesis. Neurological examination showed mild consciousness disturbance and bilateral ophthalmoplegia on admission, spastic tetraparesis with limbs hyperreflexia. Cerebrospinal fluid samples showed mild pleocytosis. MRI disclosed some small hypersignal lesions in the FLAIR. Anti-NMDA-R antibody was diagnosed upon detection of antibody in the serum. Psychiatrists and neurologists should pay more attention to the cranial, mental and behavioral involvement due to this potentially fatal disease.

Keywords: Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Disease Management, Complications

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Type of Study: case report | Subject: Special
Received: 2015/07/9 | Accepted: 2015/07/9 | Published: 2015/07/9

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