Volume 4, Issue 3 (Summer 2018)                   Caspian.J.Neurol.Sci 2018, 4(3): 91-97 | Back to browse issues page

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Alsahebfosoul F, Rahimpourkoldeh S, Eskandari N, Shaygannejad V, Ganjalikhani Hakemi M, Dabiri A, et al . Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis. Caspian.J.Neurol.Sci 2018; 4 (3) :91-97
URL: http://cjns.gums.ac.ir/article-1-233-en.html
1- Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2- Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , neskandari@med.mui.ac.ir
3- Isfahan Neurosciences Research Center, Alzahra Hospital, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
4- Department of Immunology, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (2847 Views)
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS. 
Objectives: The present study aimed to evaluate the gene expression of CD226, and its protein serum level in peripheral blood samples of MS patients and healthy individuals.
Materials & Methods: Thirty individuals with MS and 30 healthy individuals, as controls, referred to Kashani Hospital of Isfahan, Iran. CD226 expression at the transcript level and serum protein levels were measured by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assays, respectively. Statistical analyses were performed by Shapiro-Wilk test and nonparametric tests in SPSS. 
Results: The present study showed no significant differences in the gene expression of CD226 (P=0.341). The mean serum protein level of CD226 was not different between the patients and the controls (P=0.978).
Conclusion: Overall, CD226 expression has no diagnostic usefulness in MS at either the transcript or serum level. 
Keywords: Multiple Sclerosis, Demyelinating diseases, Gene expression, Cluster of Differentiation 226 (CD226) antigen
Full-Text [PDF 1301 kb]   (870 Downloads) |   |   Full-Text (HTML)  (638 Views)  
Type of Study: Research | Subject: General
Received: 2018/01/5 | Accepted: 2018/05/23 | Published: 2018/07/1

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