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Volume 9, Issue 2 (Spring 2023)
Caspian J Neurol Sci 2023, 9(2): 71-77 |
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Saberi A, Niroomand Z, Ghayeghran A, Ajamian F, Karimi A, Ghorbani Shirkouhi S, et al . The Relationship Between Bridging Integrator 1 Gene Polymorphism and Susceptibility to Alzheimer’s Disease. Caspian J Neurol Sci 2023; 9 (2) :71-77
URL: http://cjns.gums.ac.ir/article-1-619-en.html
URL: http://cjns.gums.ac.ir/article-1-619-en.html
Alia Saberi * 
1, Zohair Niroomand2 , Amirreza Ghayeghran1 , Farzam Ajamian3 , Ashkan Karimi4 , Samaneh Ghorbani Shirkouhi5 , Laleh Mirzanejad3 , Somayeh Ahmadi Gooraji6 , Sasan Andalib7
1, Zohair Niroomand2 , Amirreza Ghayeghran1 , Farzam Ajamian3 , Ashkan Karimi4 , Samaneh Ghorbani Shirkouhi5 , Laleh Mirzanejad3 , Somayeh Ahmadi Gooraji6 , Sasan Andalib7
1- Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Neurology, Rhein-Mosel-Fachklinik, Andernach, Germany
3- Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
4- Interdisciplinary Graduate Program, Centre for Vision Research, York University, Toronto, Ontario, Canada
5- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
6- Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7- Research Unit of Neurology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
2- Department of Neurology, Rhein-Mosel-Fachklinik, Andernach, Germany
3- Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
4- Interdisciplinary Graduate Program, Centre for Vision Research, York University, Toronto, Ontario, Canada
5- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
6- Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7- Research Unit of Neurology, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Abstract: (653 Views)
Background: Alzheimer’s Disease (AD) is the most common type of dementia. The role of genetic factors in AD development remains non-demonstrated.
Objectives: In this study, we aimed to investigate the association between one of the BIN1 gene’s single-nucleotide polymorphisms (SNP) rs744373 and Late-Onset Alzheimer’s Disease (LOAD) in an Iranian population in Guilan Province.
Materials & Methods: In this case-control study, 110 patients with LOAD and 110 unrelated healthy controls were recruited. Polymerase chain reaction-restriction length polymorphism (PCRRFLP) was performed for genotyping the BIN1 gene’s SNP rs744373. Electrophoresis was thereafter conducted using agarose gel and DNA-safe stain, and the gels were visualized under an Ultraviolet (UV) trans-illuminator. The allelic and genotypic frequencies were determined.
Results: The frequency of allele T (Wild-type allele) in the control and the LOAD groups was 70.9% (n=159) and 58.6% (n=129), respectively (P=0.007). The frequency of allele C in the LOAD group (41.4%) (n=91) was significantly higher than that of the control group (29.1%) (n=64) (P=0.007). BIN’s homozygous genotype (CC) frequency was significantly higher in the LOAD group than in the control group (P=0.043).
Conclusion: The rs744373 SNP of the BIN1 gene is significantly associated with the risk of developing AD in the studied population.
Objectives: In this study, we aimed to investigate the association between one of the BIN1 gene’s single-nucleotide polymorphisms (SNP) rs744373 and Late-Onset Alzheimer’s Disease (LOAD) in an Iranian population in Guilan Province.
Materials & Methods: In this case-control study, 110 patients with LOAD and 110 unrelated healthy controls were recruited. Polymerase chain reaction-restriction length polymorphism (PCRRFLP) was performed for genotyping the BIN1 gene’s SNP rs744373. Electrophoresis was thereafter conducted using agarose gel and DNA-safe stain, and the gels were visualized under an Ultraviolet (UV) trans-illuminator. The allelic and genotypic frequencies were determined.
Results: The frequency of allele T (Wild-type allele) in the control and the LOAD groups was 70.9% (n=159) and 58.6% (n=129), respectively (P=0.007). The frequency of allele C in the LOAD group (41.4%) (n=91) was significantly higher than that of the control group (29.1%) (n=64) (P=0.007). BIN’s homozygous genotype (CC) frequency was significantly higher in the LOAD group than in the control group (P=0.043).
Conclusion: The rs744373 SNP of the BIN1 gene is significantly associated with the risk of developing AD in the studied population.
Type of Study: Research |
Subject:
Special
Received: 2023/03/29 | Accepted: 2023/01/11 | Published: 2023/04/23
Received: 2023/03/29 | Accepted: 2023/01/11 | Published: 2023/04/23
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