Volume 6, Issue 4 (Autumn 2020)                   Caspian J Neurol Sci 2020, 6(4): 251-258 | Back to browse issues page

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Alidoust L, Jafari A. Exosomes: Future Perspective in Neurodegenerative Diseases. Caspian J Neurol Sci 2020; 6 (4) :251-258
URL: http://cjns.gums.ac.ir/article-1-367-en.html
Exosomes: Future Perspective in Neurodegenerative Diseases
Leila Alidoust1 , Adele Jafari * 2
1- Department of Medical Genetics, School of Medicine, Guilan University Of Medical Sciences, Rasht, Iran
2- Neuroscience Research Center, Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (1868 Views)
Neurodegeneration is a progressive and irreversible loss of neuronal cells in specific regions of the brain. Alzheimer Diseases (AD) Parkinson Disease (PD) are the most common forms of neurodegenerative diseases in older people. Exosomes are extracellular nanovesicles that have a key role in physiological processes such as intercellular communication, cell migration, angiogenesis, and anti-tumor immunity. Mounting evidence indicates the role of exosomes in neurodegenerative disorders as possible carriers of disease particles. They have several different potential applications thanks to their unique structure and functions. The present review summarizes recent studies on exosome potentials as a biomarker and therapeutic tool in neurodegenerative diseases. It also provides an overview of the structure and function of exosomes.
Keywords: Exosome, Neurodegenerative disease, MicroRNA, Biomarker
Full-Text [PDF 1323 kb]   (653 Downloads) |   |   Full-Text (HTML)  (722 Views)  
Type of Study: Research | Subject: Special
Received: 2020/12/23 | Accepted: 2020/12/20 | Published: 2020/12/20
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