شنبه 29 اردیبهشت 1403
دوره 9، شماره 4 - ( 7-1402 )
جلد 9 شماره 4 صفحات 243-229 |
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Soleimani R, Jalali M M, Bakhtiari H, Eslamdoust-Siahestalkhi F, Jalali S M. Probiotic Add-on Therapy in the First-episode Schizophrenia: A Randomized Controlled Trial. Caspian J Neurol Sci 2023; 9 (4) :229-243
URL: http://cjns.gums.ac.ir/article-1-665-fa.html
URL: http://cjns.gums.ac.ir/article-1-665-fa.html
Probiotic Add-on Therapy in the First-episode Schizophrenia: A Randomized Controlled Trial. مجله علوم اعصاب کاسپین. 1402; 9 (4) :229-243
چکیده: (348 مشاهده)
Background: Some evidence supports probiotics’ beneficial effects on clinical symptoms of patients
with schizophrenia and relieving unwanted frequently associated side effects of antipsychotic drugs
such as constipation, obesity, and metabolic disorders.
Objectives: This study aimed to assess the effect of probiotic supplements on clinical psychiatry
symptoms and metabolic indices in patients with schizophrenia.
Materials & Methods: First-episode schizophrenic patients were randomly assigned to probiotics
and placebo groups in a randomized controlled trial that took 12 weeks. The primary outcomes were
the brief psychiatric rating scale (BPRS) change scores and positive and negative syndrome scale
(PANSS). The secondary outcomes were clinical global impression-improvement scale (CGI-S),
blood pressure (BP), body mass index (BMI), lipid profiles, and fasting blood sugar (FBS).
Results: A total of 62 patients were considered for the intention-to-treat analysis (mean age, 34.7
years; 23 women; 39 men). The results showed no significant differences in the primary objectives
between the probiotic and placebo groups. In the probiotic group, subjects had lower levels of all
biochemical variables (triglycerides, cholesterol, and FBS) compared to the subjects in the placebo
group (standardized mean difference -4.3, -2.8, and -4.6, respectively; P<0.05).
Conclusion: We found that by adding probiotics to oral antipsychotics, BPRS or PANSS scores do not
improve. However, Cohen’s d for biochemical variables showed a medium to large effect size. This
study suggests probiotic supplementation may regulate and control triglycerides, cholesterol, and FBS
levels. Future studies are recommended to demonstrate these findings in the confirmatory analysis.
with schizophrenia and relieving unwanted frequently associated side effects of antipsychotic drugs
such as constipation, obesity, and metabolic disorders.
Objectives: This study aimed to assess the effect of probiotic supplements on clinical psychiatry
symptoms and metabolic indices in patients with schizophrenia.
Materials & Methods: First-episode schizophrenic patients were randomly assigned to probiotics
and placebo groups in a randomized controlled trial that took 12 weeks. The primary outcomes were
the brief psychiatric rating scale (BPRS) change scores and positive and negative syndrome scale
(PANSS). The secondary outcomes were clinical global impression-improvement scale (CGI-S),
blood pressure (BP), body mass index (BMI), lipid profiles, and fasting blood sugar (FBS).
Results: A total of 62 patients were considered for the intention-to-treat analysis (mean age, 34.7
years; 23 women; 39 men). The results showed no significant differences in the primary objectives
between the probiotic and placebo groups. In the probiotic group, subjects had lower levels of all
biochemical variables (triglycerides, cholesterol, and FBS) compared to the subjects in the placebo
group (standardized mean difference -4.3, -2.8, and -4.6, respectively; P<0.05).
Conclusion: We found that by adding probiotics to oral antipsychotics, BPRS or PANSS scores do not
improve. However, Cohen’s d for biochemical variables showed a medium to large effect size. This
study suggests probiotic supplementation may regulate and control triglycerides, cholesterol, and FBS
levels. Future studies are recommended to demonstrate these findings in the confirmatory analysis.
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