شنبه 29 اردیبهشت 1403
دوره 9، شماره 4 - ( 7-1402 )
جلد 9 شماره 4 صفحات 228-220 |
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Rezaei M, Fakhri N, Afshari D, Khazaei M. Comparing the Effectiveness and Complications of Sodae and Sodium Valproate on Migraine. Caspian J Neurol Sci 2023; 9 (4) :220-228
URL: http://cjns.gums.ac.ir/article-1-664-fa.html
URL: http://cjns.gums.ac.ir/article-1-664-fa.html
Comparing the Effectiveness and Complications of Sodae and Sodium Valproate on Migraine. مجله علوم اعصاب کاسپین. 1402; 9 (4) :220-228
چکیده: (370 مشاهده)
Background: Sodium valproate is recommended as a first-line drug to prevent migraine attacks,
and sodae is an herbal medicine.
Objectives: Sodium valproate and herbal Sodae were compared for effectiveness and side effects.
Materials & Methods: A two-center, randomized, double-blind clinical trial included migraine
patients from Kermanshah and Hamadan cities into two groups: Sodae herbal recipients and
valproate (200 mg) recipients, for 3 months. A numerical rating scale (NRS) scale was used to
measure residual pain at the end of each month of treatment. Also, a researcher-made form and the
headache impact test (HIT-6) questionnaire were used. Side effects reported by the patients were
collected, and liver function tests and complete blood cell count tests were conducted.
Results: A total of 70 migraine patients were evaluated: 33 patients (47%) in the Soda group and 37
patients (53%) in the valproate group. The NRS scores in both groups decreased constantly, with no
significant difference (P=0.303). Also, HIT-6 scores were constantly reduced in both groups with
no significant difference (P>0.05). More side effects are significantly (P=0.043) reported in the
valproate group (54.05%) than in the Sodae group (30.30%). The most common side effect in the
valproate group was drowsiness (13.5%), while among the sodae group, it was diarrhea (15.1%).
Conclusion: The sodae and valproate did not differ in headache improvement, HIT-6 scores, and
changes in laboratory parameters. However, the valproate group reported more side effects than the
Sodae group. Sodae is a suitable herbal medicine for preventing and controlling migraine attacks.
and sodae is an herbal medicine.
Objectives: Sodium valproate and herbal Sodae were compared for effectiveness and side effects.
Materials & Methods: A two-center, randomized, double-blind clinical trial included migraine
patients from Kermanshah and Hamadan cities into two groups: Sodae herbal recipients and
valproate (200 mg) recipients, for 3 months. A numerical rating scale (NRS) scale was used to
measure residual pain at the end of each month of treatment. Also, a researcher-made form and the
headache impact test (HIT-6) questionnaire were used. Side effects reported by the patients were
collected, and liver function tests and complete blood cell count tests were conducted.
Results: A total of 70 migraine patients were evaluated: 33 patients (47%) in the Soda group and 37
patients (53%) in the valproate group. The NRS scores in both groups decreased constantly, with no
significant difference (P=0.303). Also, HIT-6 scores were constantly reduced in both groups with
no significant difference (P>0.05). More side effects are significantly (P=0.043) reported in the
valproate group (54.05%) than in the Sodae group (30.30%). The most common side effect in the
valproate group was drowsiness (13.5%), while among the sodae group, it was diarrhea (15.1%).
Conclusion: The sodae and valproate did not differ in headache improvement, HIT-6 scores, and
changes in laboratory parameters. However, the valproate group reported more side effects than the
Sodae group. Sodae is a suitable herbal medicine for preventing and controlling migraine attacks.
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