@article{ author = {Amir, Fatemeh and Ahadi, Hasan and Nikkhah, Karim and Seirafi, Mohammadrez}, title = {The Effectiveness of Acceptance and Commitment Group Therapy and Group Logotherapy in Reducing Perceived Stress among MS Patients}, abstract ={Background: Previous studies suggest that group therapies, including acceptance and commitment therapy (ACT) and logotherapy, successfully reduce stress in patients. Objectives: The present study aimed to compare the effectiveness of acceptance and commitment group therapy and group logotherapy in reducing perceived stress among multiple sclerosis (MS) patients. Materials and Methods: This research was a pretest-posttest controlled quasi-experimental study. Research population was comprised of all (n=3000) MS patients who were members of Mashhad MS Society, Iran. From among 198 patients, 33 who met the inclusion criteria and scored above 45 on the Perceived Stress Scale (PSS) were selected through convenience sampling, homogenized based on their scores on PSS as well as demographic characteristics, and then assigned to three groups of 11. The first group received 12 ACT sessions and the second group received 8 sessions of group logotherapy, while no intervention was provided for the control group. Afterwards, the PSS was re-administered to all the groups. Data were analyzed using one-way ANCOVA in SPSS software version 20. Results: The results demonstrated that both group therapies reduced perceived stress among patients (p=0.001). However, ACT had a higher effect than logotherapy in reducing perceived stress (p=0.04). Conclusion: Acceptance and commitment group therapy and group logotherapy are effective in reducing perceived stress among MS patients. }, Keywords = {Multiple sclerosis, Acceptance and Commitment Therapy}, volume = {3}, Number = {4}, pages = {175-184}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.175}, url = {http://cjns.gums.ac.ir/article-1-193-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-193-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} } @article{ author = {Taherian, Reza and Arabahmadi, Mehran and Taherian, Mahdi}, title = {Investigation of the Effect of Cycloserine on Motor Function in a Rat Model of Parkinson’s disease}, abstract ={Background: Previous studies have shown cycloserine to be neuroprotective in some neurodegenerative disorders. Objectives: To investigate the effect of cycloserine on motor function in Parkinson’s disease in a rat model. Materials and Methods: Fifty-six healthy male wistar rats were used in this study and were divided into seven groups according to receiving saline, low dose (i.e. 100 mg/kg) and high dose (i.e. 200 mg/kg) of cycloserine for a short period (i.e. 8 days) (groups A-C, respectively) or long period (i.e. 16 days) (groups D-F, respectively) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-rat model of Parkinson. Also, a healthy group not receiving MPTP or any other drug was considered as the control group (group G). Apomorphine-induced rotational test (AIRT), elevated body swing test (EBST) and rotarod performance test (RPT) were done to examine behavioral performances. Results: Long-period treatment with cycloserine reduced MPTP-induced behavioral disturbances, i.e. net number of rotations in AIRT, net biased swing in EBST and reduced rotarod performance time in RPT, more than short period treatment. Although high dose of cycloserine was more effective than its low dose in reducing motor disturbance in initial trials of each test, long period treatment with low dose of cycloserine was similar to long period treatment with a high dose of it in reducing MPTP-induced Parkinsonism in EBST and RPT in latent trials. Conclusion: Long-period treatment with low-dose cycloserine seems to be the best option to obtain a sufficient neuroprotective effect for lowering motor disturbance in Parkinson’s disease.}, Keywords = {Parkinson Disease, Cycloserine, Behavior, Motor Skills}, volume = {3}, Number = {4}, pages = {185-195}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.185}, url = {http://cjns.gums.ac.ir/article-1-194-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-194-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} } @article{ author = {Zobairy, Majed and Matinhomaeei, Hasan and Hatamian, Hamidreza and Azizbeigi, Kamal and Azarbayjani, Mohamad Ali}, title = {Effect of Elastic Resistance Training and Vitamin D on Systemic Inflammation Indices in Untrained Men: A Clinical Trial}, abstract ={Background: Recent studies demonstrate the ability of vitamin D to reduce inflammation and oxidative stress.   Objectives: The current study aimed at examining the effect of vitamin D supplementation on systemic inflammation markers during an eight-week elastic resistance training (ERT) on untrained men.   Materials and Methods: Forty healthy males with no experience in resistance training were assigned to elastic training—vitamin D (ED, n=10), elastic resistance training—placebo (EP, n=10), vitamin D (VD, n=10), and control (Con, n=10) groups. ERT was performed with eight exercises three times a week on non-consecutive days for eight weeks. Also, the subjects in the ED, VD, and EP groups consumed 50,000 IU vitamin D or placebo once every two weeks. Blood samples were collected before and 72 hours after the last session of eight weeks of ERT for measuring concentration of tumor necrosis factor-alpha (TNF-alpha), Interleukin-6 (IL-6), and C reactive protein (CRP).   Results: It is found that ED elicited a significant reduction in IL6 than VD (p<0.05) and control (p<0.05). Also, there is a significant difference between EP group and VD (p<0.05) and control ones (p<0.05). However, there is no significant difference between ED and EP in the variables mentioned (p<0.05). Also, it was observed that there was no statistical significant alteration in CRP concentration between pre- and post-training (p>0.05).   Conclusion: Finally, we can claim that the combination of elastic resistance training with vitamin D did not have extra advantages in attenuation of systemic inflammatory indices when compared with the training alone. }, Keywords = {Vitamin D, Resistance Training, Interleukin-6}, volume = {3}, Number = {4}, pages = {196-205}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.196}, url = {http://cjns.gums.ac.ir/article-1-207-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-207-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} } @article{ author = {Shoeibi, Ali and Razmi, Nilufar and GhabeliJuibary, Ali and Hashemy, Seyed Isaac}, title = {The Evaluation and Comparison of Oxidative Stress in Hemorrhagic and Ischemic Stroke}, abstract ={Background: Among different mechanisms, oxidative stress has a possible role in neural injury in cerebrovascular events. Objectives: Assessment the oxidants-antioxidants imbalance in ischemic and hemorrhagic strokes. Materials and Methods: Serum level of malondialdehyde, the main marker of lipid peroxidation, and total antioxidant capacity were measured in a group of 48 stroke patients consisting of 24 ischemic and 24 hemorrhagic cases with confirmed diagnosis by brain CT scan. Lesion volume and modified National Institutes of Health Stroke Scale (NIHSS) in ischemic stroke, as well as location and volume of hematoma in hemorrhagic stroke based on the first brain CT scan were determined as study variables. Results: These two major groups did not have different oxidative profile. Low levels of total antioxidant capacity and high levels of malondialdehyde were associated with higher lesion volume in hemorrhagic stroke patients. Conclusions: This data suggested that oxidative stress is associated with lesion volume and therefore severity of hemorrhagic stroke.}, Keywords = {Oxidative Stress, Malondialdehyde, Stroke}, volume = {3}, Number = {4}, pages = {206-213}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.206}, url = {http://cjns.gums.ac.ir/article-1-203-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-203-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} } @article{ author = {Etemadifar, Masoud and Ghadimi, Mozhgan and Ghadimi, Keyvan and Alsahebfosoul, Fereshteh}, title = {The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study}, abstract ={Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients. Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal fluid (CSF) contents. Objectives: The current study aimed at measuring amyloid β (Aβ) serum levels in patients with relapsing-remitting MS. Materials and Methods: In the current case-control study, the serum levels of Aβ were measured in 48 patients with RRMS and 33 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique in Isfahan, Iran, from 2014 to 2016. Data analysis was conducted with SPSS. Results: The mean serum level of Aβ in the case (patients with RRMS) and control groups were 192.75±125.65 and 128.11±85.20 pg/mL, respectively; so serum Aβ levels in the RRMS group was significantly higher than healthy controls (p=0.02). Also, there was a positive significant correlation between the serum Aβ levels and the expanded disability status scale (EDSS) (r=+0.85, p<0.0001). Conclusions: Owing to the increase of serum Aβ level in patients with RRMS and its significant increase in severe MS cases (higher EDSS scores), so serum Aβ level can be considered as a marker for MS and its progression.}, Keywords = {Multiple Sclerosis, Amyloid, Enzyme-Linked Immunosorbent Assay}, volume = {3}, Number = {4}, pages = {214-221}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.214}, url = {http://cjns.gums.ac.ir/article-1-204-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-204-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} } @article{ author = {Mehvari, Jafar and Zare, Mohammad and Andami, Rooholla and Ghadimi, Keyvan and Tabrizi, Nasim}, title = {Ictal and Interictal Electroencephalography of Mesial and Lateral Temporal Lobe Epilepsy; A Comparative Study}, abstract ={Background: Epilepsy is considered as one of the most important disorders in neurology. Temporal lobe epilepsy is a form of epilepsy including two main types of mesial and lateral (neocortex). Objectives: Determination and comparison of electroencephalogram (EEG) pattern in the ictal and interictal phases of mesial and lateral temporal lobe epilepsy. Materials and Methods: This cross-sectional descriptive study included 80 patients with mesial and lateral temporal lobe epilepsy who satisfied the inclusion criteria. The patients were monitored using EEG, and then the EEG results were compared between two groups of temporal epilepsies. Results: There was no significant difference between two groups of patients (mesial and lateral temporal lobe epilepsy) in terms of the type of seizure, history of tumor or trauma or hypoxia, and duration of seizure history (p>0.05). The ictal wave onset in 52.5% of the patients was in the left temporal region, and the ictal wave onset in 58.75% of patients was the slow wave. There was no significant difference between the two groups of patients in terms of ictal wave onset and its location. Conclusions: According to the results, EEG is a good method for detecting temporal lobe epilepsy, but it does not help to differentiate the type of mesial and lateral temporal epilepsy. In order to distinguish between these two types, EEG alone is not helpful, and other diagnostic methods are required.}, Keywords = {Epilepsy, Temporal Lobe, Electroencephalography}, volume = {3}, Number = {4}, pages = {222-230}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.222}, url = {http://cjns.gums.ac.ir/article-1-205-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-205-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} } @article{ author = {Etemadifar, Masoud and Fazli, Ali}, title = {Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders}, abstract ={Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders.}, Keywords = {Myelin-Oligodendrocyte Glycoprotein, Immunoglobulins, Myelitis, Transverse, Optic Neuritis}, volume = {3}, Number = {4}, pages = {231-240}, publisher = {}, doi = {10.29252/nirp.cjns.3.11.231}, url = {http://cjns.gums.ac.ir/article-1-206-en.html}, eprint = {http://cjns.gums.ac.ir/article-1-206-en.pdf}, journal = {Caspian Journal of Neurological Sciences}, issn = {2383-4307}, eissn = {2423-4818}, year = {2017} }