Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1394
12
1
gregorian
2016
3
1
2
1
online
1
fulltext
en
Helicobacter pylori and Migraine: Is Eradication of Helicobacter pylori Effective in Relief of Migraine Headache?
تخصصي
Special
پژوهشي
Research
<p style="margin-right:1.7pt;"><strong>Background: </strong>Association between <em>Helicobacter pylori</em> (HP) infection and migraine and the effect of HP eradication on relief of migraine headache have been studied but the results are controversial.</p>
<p style="margin-right:1.7pt;"><strong>Objectives: </strong>To evaluate the effect of HP eradication in treatment of patients affected by migraine.</p>
<p style="margin-right:1.7pt;"><strong>Materials and Methods: </strong>Eighty consecutive HP infected patients affected by migraine without aura were enrolled in this clinical trial. They have referred to an endoscopy clinic for work-up of HP infection from October 2013 to November 2014. Patients were randomly assigned in 2 groups using 2 different regimens; Group A: migraine treatment and a 14-day triple therapy for HP infection and Group B: migraine treatment without HP eradication. The mean duration (hour), headache severity (MIDAS) and the frequency (per month) of clinical headache attacks were calculated upon enrollment in the study and at 6 months and 12 months after treatment. All data were analyzed using SPSS version 16. Comparison of categorical variables across the groups was performed using Chi-square test.</p>
<p style="margin-right:1.7pt;"><strong>Results: </strong>In group A, HP infection was eradicated in 34 of 40 patients (85%). After treatment in eradicated patients compared with the control group there was significant decrease in severity and frequency (but not in duration) of the migraine attacks at 6 months (<em>p</em><0.001) and significant decrease in intensity, frequency and duration of the migraine attacks at 12 months (<em>p</em><0.001).</p>
<p style="margin-right:1.7pt;"><strong>Conclusion: </strong>HP should be considered and examined in migranous patients and eradication treatment can be beneficial for relief of clinical attacks.</p>
Helicobacter pylori, Disease Eradication, Migraine Disorders
29
35
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-29&slc_lang=en&sid=1
Mohammadreza
Seyyedmajidi
No
Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Seyed-Amir
Banikarim
No
Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Afsaneh
Ardalan
No
Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Seyed-Hossein
Hozhabrossadati
No
Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Alireza
Norouzi
No
Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Jamshid
Vafaeimanesh
Yes
Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran ; j.vafaeemanesh@muq.ac.ir