Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1400
4
1
gregorian
2021
7
1
7
3
online
1
fulltext
en
The Relationship Between Serum Dehydroepiandrosterone Concentration and Memory Function in the Elderly
تخصصي
Special
پژوهشي
Research
<strong>Background:</strong> World population is rapidly aging, and the elderly are most at risk of cognitive impairment. Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEAS) have an essential effect on neuroprotection and might effectively improve cognition and memory.<br>
<strong>Objectives</strong>: This study aimed to investigate the relationship between the level of DHEA and memory function in the elderly.<br>
<strong>Materials & Methods:</strong> The present study was a cross-sectional analytical study, and the study population included the elderly (age 60 years and older) living in Rasht City, the north of Iran, in 2020. The participants completed a demographic questionnaire and Wechsler Memory Scale (WMS), and their serum DHEA levels were measured by the hormonal automation method. The data were analyzed by SPSS v. 23, using t-test, the one-way Analysis of Variance (ANOVA), Pearson and Spearman correlation coefficient.<br>
<strong>Results:</strong> The participants included 100 older people (57 females and 43 males) with a Mean±SD age of 67.38±5.39 years. There was no correlation between serum DHEA concentrations with a total score of the WMS (r=0.117, P=0.247). However, the correlation between the DHEA level and the scores of personal and current information and visual reproduction subscales were statistically significant (r=0.219, P=0.029; r=0.206, P=0.04).<br>
<strong>Conclusion:</strong> The study indicates that the total memory score was not associated with the level of serum DHEA.
Dehydroepiandrosterone, Memory, Wechsler Memory Scale
133
139
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-135&slc_lang=en&sid=1
Elahe
Abdollahi
0000-0002-2554-5213
Yes
Kavosh Cognitive Behavior Sciences and Addiction Research Center, Department of Psychiatry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Golsa
Olia
0000-0002-2093-7875
No
Kavosh Cognitive Behavior Sciences and Addiction Research Center, Department of Psychiatry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Fatemeh
Eslamdoust-Siahestalkhi
0000-0002-7715-8389
No
Kavosh Cognitive Behavior Sciences and Addiction Research Center, Department of Psychiatry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Robabeh
Soleimani
soleimani.dr@gmail.com
0000-0003-1463-0380
No
Kavosh Cognitive Behavior Sciences and Addiction Research Center, Department of Psychiatry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.