Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1393
12
1
gregorian
2015
3
1
1
1
online
1
fulltext
en
The Serum Level of Estrogen and Progesterone and Their Ratio in Patients with Ischemic Stroke: A Comparative Study
تخصصي
Special
پژوهشي
Research
<p>Background: The role of estrogen and progesterone in stroke is suggested in previous studies, but yet is controversial. Objectives: Comparing the plasma levels of estrogen and progesterone and their ratio in ischemic stroke patients and healthy population. Materials and Methods: This cross-sectional comparative study was conducted from March to September of 2013. Sixty-six female patients older than 60 years with ischemic stroke who referred within the first 12 hour of their neurologic symptoms were included. A total of 48 women who were in the same age range comprised the control group. The serum levels of progesterone and 17-β-estradiol concentrations were measured. The data were analysed by Chi2 test, univariate and logistic regression models in SPSS software 19. Results: There was no significant difference between case and control groups in serum levels of estrogen (28.66 ± 13.60 vs. 35.72 ± 28.36) and progesterone (1.07 ± 0.83 vs. 1.40 ± 1.87) and their ratio (p > 0.05). But in multivariate analysis, estrogen (p = 0.033), progesterone (p = 0.02) and the interaction between them (p = 0.013) remained as associated factors. In addition, the higher ratio of estrogen to progesterone indicates the less ability of patients, which one unit increase in this ratio results in 0.072 reduction in NIHSS (National Institutes of Health Stroke Scale) score. Conclusions: The level of estrogen and progesterone and interaction between them are associated with ischemic stroke. The ratio of estrogen to progesterone has reverse association with score of the ability of patient according to NIHSS.</p>
Estrogens, Progesterone, Stroke
35
42
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-9&slc_lang=en&sid=1
Alia
Saberi
No
Neurology Department, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Milad
Javadpoor
Yes
Neurology Department, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran ; milad.javadpoor@yahoo.com
Nastaran
Farahmand
No
Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Ehsan
Kazem-Nezhad
No
Biostatistics Department, Faculty of Nursery, Guilan University of Medical Sciences, Rasht, Iran