Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1393
12
1
gregorian
2015
3
1
1
1
online
1
fulltext
en
Effect of Hydroethanolic Extract of Rubus fruticosus on Neuropathic Pain in Wistar Diabetic Rats
تخصصي
Special
پژوهشي
Research
<p>Background: Diabetes mellitus is the most common metabolic disorder with many complications such as neuropathic pain which relief from it is a dilemma. Objectives: To investigate the effect of hydroethanolic extract of Rubus fruticosus on neuropathic pain in diabetic rats. Materials and Methods: In this experimental case –control study, forty eight male Wistar rats (250±20 g) were divided randomly to non-diabetic and diabetic groups. Streptozotocin (60 mg/kg, intra-peritoneal) was used to induce experimental diabetes. Each group was divided into three groups: receiving orally normal saline, 100 and 200 mg/kg doses of Rubus fruticosus extract for 30 days. At the end the rats were subjected to Tail-Flick test. The data were analyzed by one-way and two-way ANOVA followed by Tukey’s test in SPSS 21. Results: In a paired comparison, all diabetic groups had shorter latency of tail-flicking time (p < 0.01) and lower pain tolerance threshold. Also among diabetic rats, significant differences existed between saline group and group receiving the extract at a dose of 100 mg/Kg (p < 0.01), between saline group and the group receiving the extract at a dose of 200 mg/Kg (p < 0.001) and also between the groups receiving extract at two different doses (p < 0.001). But, only diabetic group receiving the extract at a dose of 200 mg/Kg showed positive significant difference with non-diabetic control group (p < 0.01). Conclusions: The hydroethanolic extract of Rubus fruticosus can heighten the pain tolerance threshold and reduce the neuropathic pain induced by diabetes mellitus.</p>
Rubus fruticosus, Diabetes Mellitus, Diabetic Neuropathies
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http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-8&slc_lang=en&sid=1
Ali
Gomar
Yes
Department of Biology, Science & Research Institute, Islamic Azad University, Tehran, Iran ; gomar.ucla@yahoo.com
Abdolkarim
Hosseini
No
Department of Physiology, Faculty of Biological Science, Shahid Beheshti University, Tehran, Iran
Naser
Mirazi
No
Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamadan, Iran
Mojtaba
Gomar
No
Student of Surgical technology, Faculty of Para medicine, Aja University of Medical Sciences, Tehran, Iran