Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1397
7
1
gregorian
2018
10
1
4
4
online
1
fulltext
fa
Intravenous Thrombolysis, Time Window, Dosage, and Off-Label
تخصصي
Special
گزارش مورد
case report
<div style="text-align: justify;">Despite the development of Intravenous thrombolysis with tissue Plasminogen Activator (IVtPA) guidelines in each affiliated stroke center, protocol violations may be observed in each hospital with IVtPA facilities. An extensive search of scientific electronic databases including PubMed, OVID, Index Medicus, Index Copernicus, Google, ISI, and Scopus was performed with keywords of Thrombolysis, Off-label, Out of Protocol, Violation, Time Window, Dose, tPA, and Stroke terminated on 01 May 2018. Safety and functional outcomes are less favorable beyond three hours; however, the wider time window until 4.5 hours is recommended. Lower dose of alteplase (0.6 mg/kg) is approved in Japan. The proposed dose of tPA in Iranian population is similar to that of the Japanese. Overall, the outcomes in patients treated with off-label IVtPA or protocol violation were better than those of the controls based on registry data. There is little disagreement about time window of IVtPA. The dose of 0.6 mg/kg is used in some Asian countries with similar therapeutic results.</div>
Stroke, Tissue Plasminogen Activator
178
183
http://cjns.gums.ac.ir/browse.php?a_code=A-10-143-3&slc_lang=fa&sid=1
Kavian
Ghandehari
kavianghandehari@yahoo.com
0000-0002-5664-2761
Yes
Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sharife
Shahedi
No
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Zahra
Valipour
No
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Reza
Sobhani
No
Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hojat
Salehian
No
Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Shokat
Nazemian
0000-0001-7988-7342
No
Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Masumeh
Rezae
No
Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran