%0 Journal Article %A Seyyedmajidi, Mohammadreza %A Banikarim, Seyed-Amir %A Ardalan, Afsaneh %A Hozhabrossadati, Seyed-Hossein %A Norouzi, Alireza %A Vafaeimanesh, Jamshid %T Helicobacter pylori and Migraine: Is Eradication of Helicobacter pylori Effective in Relief of Migraine Headache? %J Caspian Journal of Neurological Sciences %V 2 %N 1 %U http://cjns.gums.ac.ir/article-1-83-en.html %R 10.18869/acadpub.cjns.2.4.29 %D 2016 %K Helicobacter pylori, Disease Eradication, Migraine Disorders, %X Background: Association between Helicobacter pylori (HP) infection and migraine and the effect of HP eradication on relief of migraine headache have been studied but the results are controversial. Objectives: To evaluate the effect of HP eradication in treatment of patients affected by migraine. Materials and Methods: Eighty consecutive HP infected patients affected by migraine without aura were enrolled in this clinical trial. They have referred to an endoscopy clinic for work-up of HP infection from October 2013 to November 2014. Patients were randomly assigned in 2 groups using 2 different regimens; Group A: migraine treatment and a 14-day triple therapy for HP infection and Group B: migraine treatment without HP eradication. The mean duration (hour), headache severity (MIDAS) and the frequency (per month) of clinical headache attacks were calculated upon enrollment in the study and at 6 months and 12 months after treatment. All data were analyzed using SPSS version 16. Comparison of categorical variables across the groups was performed using Chi-square test. Results: In group A, HP infection was eradicated in 34 of 40 patients (85%). After treatment in eradicated patients compared with the control group there was significant decrease in severity and frequency (but not in duration) of the migraine attacks at 6 months (p<0.001) and significant decrease in intensity, frequency and duration of the migraine attacks at 12 months (p<0.001). Conclusion: HP should be considered and examined in migranous patients and eradication treatment can be beneficial for relief of clinical attacks. %> http://cjns.gums.ac.ir/article-1-83-en.pdf %P 29-35 %& 29 %! %9 Research %L A-10-32-29 %+ Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran ; j.vafaeemanesh@muq.ac.ir %G eng %@ 2383-4307 %[ 2016