AU - Saberi, Alia AU - Ghayegran, Amirreza AU - Abbasalizade, Mojtaba AU - Ehtiatkar, Zeinab AU - Ghorbani Shirkouhi, Samaneh AU - Shahshahani, Parisa AU - Hatamian, Hamidreza AU - Andalib, Sasan TI - The Outcome of Treatment With Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke PT - JOURNAL ARTICLE TA - gums-cjns JN - gums-cjns VO - 7 VI - 3 IP - 3 4099 - http://cjns.gums.ac.ir/article-1-439-en.html 4100 - http://cjns.gums.ac.ir/article-1-439-en.pdf SO - gums-cjns 3 ABĀ  - Background: Thrombolytic therapy is the recommended treatment of acute ischemic stroke. It is crucial to evaluate the treatment results with recombinant Tissue Plasminogen Activator (r-TPA) in patients with acute stroke. Objectives: This study aimed to evaluate treatment outcomes with r-TPA in patients with acute stroke in a referral stroke center in Iran. Materials & Methods: In this retrospective study, 87 patients with symptoms of acute stroke were examined. They were referred to a stroke center in Gilan Province, Iran, from June 2016 to April 2020 and received r-TPA (0.9 mg/kg). Demographic information, the time interval between the onset of symptoms and r-TPA administration, complications, and National Institutes of Health Stroke Scale (NIHSS) upon arrival and discharge and death of patients were extracted from their hospital files. The paired t-test, independent t-test, and Pearson correlation test were used to compare variables using IBM SPSS for Windows version 20.0 (IBM Corp., Armonk, NY, USA). Results: The Mean±SD of NIHSS reduced from 14.7±6.4 to 8.9±7.6 (P<0.001). The most common complication was Intracerebral Hemorrhage (ICH) (12.6%). The hospital mortality rate was 23%. ICH occurred among 40% (n=8) of those who expired, and 4.47% (n=3) of them survived, and this difference was significant (P<0.001). Conclusion: The recovery with r-TPA administration in the stroke center was acceptable. Mortality and ICH occurrence rates were higher than other non-Iranian studies. It seems that we should change the case selection criteria and prescription dose to achieve better results of treatment with TPA. CP - IRAN IN - LG - eng PB - gums-cjns PG - 148 PT - Research YR - 2021