RT - Journal Article T1 - Tumefactive Brain Lesions in Patients with Neuromyelitis Optica Spectrum Disorder JF - gums-cjns YR - 2019 JO - gums-cjns VO - 5 IS - 2 UR - http://cjns.gums.ac.ir/article-1-257-en.html SP - 96 EP - 100 K1 - Neuromyelitis Optica K1 - Magnetic Resonance Imaging K1 - Brain AB - Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune neurological disorder that is characterized by optic neuritis and longitudinally-extended transverse myelitis lesions in spinal segments. Magnetic Resonance Imaging (MRI) findings are part of the diagnostic process in NMOSD patients, and abnormal lesion patterns may cause deviation from a correct diagnosis. Clinical Presentation and Intervention: A 43-year-old female patient with abrupt cognitive loss, motor dysfunction and tumefactive spread of the demyelinating lesions in her brain presented to the Neurology Clinic of Kashani Hospital. Anti Aquaporine 4(AQP-4) antibody was observed, and the patient responded well to the NMOSD treatment. Conclusion: NMOSD can be considered a differential diagnosis during an episode of Fulminant Demyelinating Disorder (FDD) with the tumefactive spread of the lesions. LA eng UL http://cjns.gums.ac.ir/article-1-257-en.html M3 10.32598/CJNS.5.17.96 ER -