دوره 8، شماره 4 - ( 6-1401 )                   جلد 8 شماره 4 صفحات 212-206 | برگشت به فهرست نسخه ها


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چکیده:   (377 مشاهده)
Background: As previous studies show, several effects of morphine are induced by the dopaminergic
system. Sulpiride is a dopamine D2 receptor (DAD2) antagonist widely used in clinics to treat DArelated
disorders. DAD2 receptors are abundant at hippocampal cornu ammonis (CA1).
Objectives: This study aimed to investigate the possible interaction of morphine and sulpiride on
DA synapses in CA1.
Materials & Methods: In this study, 48 Wistar rats weighing 220 to 250 g were used. These animals
were classified into eight groups (6 rats per group): saline control group (1 ml/kg), morphine
group (5 mg/kg), sulpiride groups alone (1, 2, and 4 mg/kg) and sulpiride groups (1, 2, and 4 mg/
kg)+morphine (5 mg/kg). Saline or substances were injected once intraperitoneally. After 48 h, the
animals’ brains were removed under anesthesia and placed in 10% formalin for fixation. Then, 3- to
4-μm slices were cut from these tissues, and the DA synapse was examined by histochemistry and
immunohistochemistry techniques. The data were statistically analyzed by the analysis of variance.
Results: The control group had DA synapses and healthy neurons. A relative increase in DA
synapses compared to the control group was observed in the morphine and single sulpiride groups.
However, in sulpiride+morphine groups, DA synapses were reduced compared to morphine or
sulpiride alone, but neurons were not destroyed.
Conclusion: The interaction effect of sulpiride and morphine in the CA1 region may decrease DA
synapses.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1401/6/23 | پذیرش: 1401/7/6 | انتشار: 1401/7/6

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