دوره 7، شماره 4 - ( 7-1400 )                   جلد 7 شماره 4 صفحات 201-193 | برگشت به فهرست نسخه ها


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Hajizadeh N, Farjah G H, Karimipour M, Pourheidar B. Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats. Caspian J Neurol Sci 2021; 7 (4) :193-201
URL: http://cjns.gums.ac.ir/article-1-465-fa.html
Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats. مجله علوم اعصاب کاسپین. 1400; 7 (4) :193-201

URL: http://cjns.gums.ac.ir/article-1-465-fa.html


چکیده:   (1278 مشاهده)
Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia.
Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury.
Materials & Methods: A total of 35 male rats (250-300 g) were divided randomly into five groups:  intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dose CH (I-R+10 mg/kg CH), and high-dose CH (I-R+20 mg/kg CH). Abdominal aorta clamping was done for 60 min. Seventy-two hours after I-R, animals were evaluated for neurologic function, biochemical analysis, and histology. The data analysis was conducted by SPSS v. 16 using ANOVA and Kruskal-Wallis and Mann-Whitney U tests.
Results: The mean Motor Deficit Index (MDI) score and white matter damage in the CH (20 mg/kg) group were lower than in the DMSO group (P=0.032). The mean plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the CH groups were lower than that of the DMSO group (P<0.05). The plasma level of Total Antioxidant Capacity (TAC) in the CH (20 mg/kg) group was higher than in the DMSO group (P=0.032). In addition, the plasma level of catalase in the CH (20 mg/kg) group was higher than in the DMSO and CH (10 mg/kg) groups (P<0.001). The average number of normal motor neurons in the experimental groups was lower than in the sham surgery group (P<0.001). 
Conclusion: These results showed that CH may be effective in reducing spinal cord I-R injury.
 
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1400/3/21 | پذیرش: 1400/6/7 | انتشار: 1400/7/9

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