دوره 7، شماره 3 - ( 5-1400 )                   جلد 7 شماره 3 صفحات 172-179 | برگشت به فهرست نسخه ها


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hedayati Ch M, Abedinzade M, Khanaki K, Khakpour Tleghani B, Golshekan M, Mohammadi E. Comparative Protective Effects of Viola Spathulata, Urtica Dioica, and Lamium Album on Endoplasmic Reticulum (ER) Stress in Rat Stroke Model. Caspian.J.Neurol.Sci. 2021; 7 (3) :172-179
URL: http://cjns.gums.ac.ir/article-1-442-fa.html
Comparative Protective Effects of Viola Spathulata, Urtica Dioica, and Lamium Album on Endoplasmic Reticulum (ER) Stress in Rat Stroke Model. مجله علوم اعصاب کاسپین. 1400; 7 (3) :172-179

URL: http://cjns.gums.ac.ir/article-1-442-fa.html


چکیده:   (271 مشاهده)
Background: Pathological conditions, including ischemic stroke, are associated with severe Endoplasmic Reticulum (ER) stress that induces apoptosis and cell death. Herbal medicines are natural treatments with few side effects in such situations.
Objectives: In the present study, we examined the probable neuroprotective effects of Viola spathulata, Lamium album, and Urtica dioica on splicing of ER stress mRNA gene marker (X-box Binding Protein-1 [XBP-1]) and Unfolded Protein Response (UPR) activation in the brain of the rat stroke model.
Materials & Methods: Sixty male Wistar albino rats (weight: 220-250 g) were selected for this study and divided into two major groups. The first major group comprised the healthy animals that are subdivided into groups number 1 to 5. The second major group comprised the Middle Cerebral Artery Occlusion (MCAO) group subdivided into groups number 6-10. The reverse transcriptionpolymerase chain reaction was performed after pretreatment with different herbal extracts (5, 10 mg/kg), Viola spathulata, and 100 mg/ kg Urtica dioica and Lamium album). The results were analyzed by one-way analysis of variance in IBM SPSS v. 22.
Results: MCAO-induced ischemia caused a marked increase in XBP-1 splicing in all rats of the MCAO group in comparison to the control groups (P<0.05), and pretreatment with 3 herbal extracts dramatically decreased target gene splicing in the MCAO studied groups (P<0.05).
Conclusion: All three herbal extracts of U. dioica, L. album, and V. spathulata had the promising potential to use as a neuroprotective agent by reducing ER stress.
متن کامل [PDF 1739 kb]   (178 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1400/6/3 | پذیرش: 1400/4/16 | انتشار: 1400/4/16

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به مجله علوم اعصاب کاسپین می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2021 CC BY-NC 4.0 | Caspian Journal of Neurological Sciences

Designed & Developed by : Yektaweb