Background: Multiple Sclerosis (MS) is a neuroinflammatory autoimmune disease of the central nervous system. ANKRD55 rs6859219 Single Nucleotide Polymorphisms (SNPs) are reported as a potential novel MS risk gene, but the biological reasons underlying this correlation are still mysterious.
Objectives: This study aimed to investigate the potential association of ANKRD55 rs6859219 SNP with the risk of MS in Iranian patients.
Materials & Methods: Blood samples were taken from 80 patients and healthy individuals. Afterward, the effects of some related-risk factors, such as age, gender, smoking status, drug allergy, and exposure to chemicals (such as detergents, cleansing chemical, acids, etc., in their common work area or their daily home exposure) were measured on the incidence of Relapsing-Remitting MS (RRMS) patients. Polymerase Chain Reaction (PCR) was performed, and the PCR products were genotyped using the Sanger sequencing system.
Results: The GT genotype of ANKRD55 rs6859219 SNP more increased in MS patients than healthy subjects, and a significant association was found between MS and the rs6859219 SNP in the single-variable association analysis (P=0.04). In the additive model, our findings indicated that the rs6859219 SNP increased the risk of MS. Additionally, the results of all crude models, additive, recessive, dominant, and overdominant, were significantly different in participants with MS compared to the controls.
Conclusion: Eventually, the GT genotype of ANKRD55 rs6859219 SNP significantly increased the risk of MS compared to the TT genotype.

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