دوره 6، شماره 2 - ( 1-1399 )                   جلد 6 شماره 2 صفحات 93-84 | برگشت به فهرست نسخه ها


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Hoveyda S, Khalatbari J, Peymani J, Ahadi H. Symptom Dimensions and Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Obsessive-compulsive Disorder. Caspian J Neurol Sci 2020; 6 (2) :84-93
URL: http://cjns.gums.ac.ir/article-1-325-fa.html
Symptom Dimensions and Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Obsessive-compulsive Disorder. مجله علوم اعصاب کاسپین. 1399; 6 (2) :84-93

URL: http://cjns.gums.ac.ir/article-1-325-fa.html


چکیده:   (2038 مشاهده)
Background: Obsessive-Compulsive Disorder (OCD) is a serious neuropsychiatric disorder. The clinical prominence of the OCD symptoms dimensions and Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism are of significant importance. Objectives: The present study aimed to investigate the symptom dimensions and BDNF val66Met polymorphism genotype in Iranian patients with OCD.
Materials and Methods: A total of 83 patients diagnosed with OCD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM5) criteria, and 83 matched controls were included this case-control study. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to investigate symptom dimensions. In addition, BDNF val66Met polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCRRFLP) method.
Results: The obtained data indicated that the most prevalent obsession was contamination (62.6%) and the most prevalent compulsion was cleanliness (69.8%). Furthermore, there was a significant relationship between the genotypes of BDNF val66Met polymorphism in OCD (P<0.01). Besides, carrying the” T” allele confers increased the risk for the presence of OCD [χ2 =4.7, P=0.003; OR (95%) 1.93 (1.24-2.99)].
Conclusion: The symptoms dimensions of OCD in the Iranian sample were similar to other populations. Moreover, the findings suggested an association between BDNF val66Met polymorphism genotype and OCD in the exp
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1399/6/4 | پذیرش: 1399/3/23 | انتشار: 1399/3/23

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