Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1394
4
1
gregorian
2015
7
1
1
2
online
1
fulltext
en
Cell Therapy for Traumatic Brain Injury: Opportunities and Pitfalls
تخصصي
Special
مروری
Review
Today, stem cell transplantation is a hot topic in scientific circles as a novel therapeutic approach to repair the structure and function of central nervous system. The safe and neuroprotective effects of cell therapy in models and traumatic brain injury patients were evaluated in many experimental and clinical studies in recent decade and somewhat promising results were provided to the scientific community. Nevertheless, there are still obstacles in translating experimental studies in the laboratory into clinical practice that should not be overlooked. In this review study, a brief explanation is provided about biological events and endogenic neurogenesis and angiogenesis after TBI the performance of transplanted cells in restoration of damaged neurons the role and potential use of mesenchymal stem cells as adult stem cells preferred in cell transplantation and clinical trials ever conducted in this area features of cell transplant candidates who will most benefit from transplantation, the type of and proper time for cell transplantation, optimal method for conducting transplant to deliver cells to the brain, and the best dose for effectiveness of transplantation. Finally, the various neuroimaging techniques are discussed, which are used to track and evaluate the survival and implantation of transplanted cells.
Trauma, Nervous System, Brain Injuries, Neurogenesis, Angiogenesis, Mesenchymal Stem Cells, Cell Grafting, Cell Tracking
37
51
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-17&slc_lang=en&sid=1
Sara
Ramezani
Yes
Neuroscience Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran ; s.ramezanislp@gmail.com
Zoheir
Reihanian
No
Neurosurgery Department, Guilan University of Medical Sciences, Rasht, Iran
Mohammad-Taghi
Joghataei
No
Neuroscience Department, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
Shahrokh
Yousefzadeh
No
Neurosurgery Department, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran