Caspian Journal of Neurological Sciences
مجله علوم اعصاب کاسپین
Caspian J Neurol Sci
Literature & Humanities
http://cjns.gums.ac.ir
1
admin
2383-4307
2423-4818
10.32596
en
jalali
1397
10
1
gregorian
2019
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1
5
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online
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fulltext
en
ارتباط بین مصرف نمک و پتاسیم با مالتیپل اسکلروزیس
The Association Between Salt and Potassium Intake with Multiple Sclerosis
تخصصي
Special
پژوهشي
Research
<div style="text-align: justify;"><strong>Background:</strong> The number of patients with Multiple Sclerosis (MS) is increasing in Iran. Studies have shown that high sodium chloride (salt) and low potassium intake are associated with the development of MS. High physiological salt concentrations can lead to the induction of Interleukin-17 (IL-17) accompanied by the excessive generation of helper T-17 cells (Th-17). This cytokine plays a critical role in the pathogenesis of autoimmune diseases. This is while potassium supplementation has a blocking effect on IL-17 production.<br>
Objectives: Because of the role of salt and potassium in Th 17 development, we hypothesized that sodium chloride (NaCl) would be higher and potassium (K) would be lower in MS patients than healthy controls. Therefore, we investigated the association between salt and potassium intake with MS in Isfahan City population, Iran.<br>
<strong>Materials & Methods:</strong> A case-control study containing 23 patients and 23 healthy controls was performed in Isfahan City, Iran, 2016. NaCl and K levels were measured in 24-h urine. Using the Chi-square test, the patients’ laboratory values were compared with the healthy controls. The level of significance was set at P<0.05 in all analyses. All calculations were performed in SPSS, version 23.0.<br>
<strong>Results:</strong> In this study, urine Na levels were somewhat higher in cases than in controls (Interquartile Range [IQR]; 160[140-211] mEq/24 h vs. 128[83-166] mEq/24 h]) (P=0.027). These results show a significant relationship between urine-Na and MS. Urine k concentrations were lower in cases than controls [IQR; 47(27-70) mEq/24 h vs. 50(29-56) mEq/24 h] but we did not find a significant difference between two groups (P=0.807).<br>
<strong>Conclusion:</strong> Based on this study, a high level of sodium intake may be associated with MS; however, we did not find a significant difference between patients and controls with regard to potassium level.</div>
<div style="text-align: justify;"></div>
Multiple Sclerosis, Sodium chloride, Potassium, Th 17 cells, Interleukin-17
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27
http://cjns.gums.ac.ir/browse.php?a_code=A-10-161-1&slc_lang=en&sid=1
Sarah
Ghorbani
ghorbani.sara1995@gmail.com
0000-0001-5921-6410
No
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Hamidreza
Hatamian
No
Department of Neurology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
Amirhossain
Mahmoudzadeh
Ahm200975@gmail.com
No
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Sina
Raeisi
raeisie.sn@gmail.com
No
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammadjavad
Eslami
mjeslami19@gmail.com
No
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Masoud
Etemadifar
etemadifar@med.mui.ac.ir
0000-0002-0066-3782
Yes
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Fatemeh
Shafaei
No
Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran