TY - JOUR JF - gums-cjns JO - Caspian J Neurol Sci VL - 3 IS - 4 PY - 2017 Y1 - 2017/10/01 TI - Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders TT - N2 - Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders. SP - 231 EP - 240 AU - Etemadifar, Masoud AU - Fazli, Ali AD - Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran; ali96fazli@yahoo.com KW - Myelin-Oligodendrocyte Glycoprotein KW - Immunoglobulins KW - Myelitis KW - Transverse KW - Optic Neuritis UR - http://cjns.gums.ac.ir/article-1-206-en.html DO - 10.29252/nirp.cjns.3.11.231 ER -