RT - Journal Article T1 - Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders JF - gums-cjns YR - 2017 JO - gums-cjns VO - 3 IS - 4 UR - http://cjns.gums.ac.ir/article-1-206-en.html SP - 231 EP - 240 K1 - Myelin-Oligodendrocyte Glycoprotein K1 - Immunoglobulins K1 - Myelitis K1 - Transverse K1 - Optic Neuritis AB - Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders. LA eng UL http://cjns.gums.ac.ir/article-1-206-en.html M3 10.29252/nirp.cjns.3.11.231 ER -