دوره 2، شماره 1 - ( 12-1394 )                   جلد 2 شماره 1 صفحات 42-53 | برگشت به فهرست نسخه ها

DOI: 10.18869/acadpub.cjns.2.4.42


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چکیده:   (3778 مشاهده)

Background: Gliomas are the most common primary neoplasms of the central nervous system. Relative cerebral blood volume (rCBV) could estimate high-grade Gliomas computed with dynamic susceptibility contrast MR imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier.

Objectives: Our intent was to clarify the usefulness of diffusion-weighted magnetic resonance imaging (DWI) and perfusion weighted magnetic resonance imaging (PWI) in the grading of Gliomas.

Materials and Methods: Both PWI and DWI with a three-tesla scanner investigated nineteen consecutive patients with Gliomas. The means of rCBV and ADC values have been compared among the tumor groups with t-test and ROC curve analysis to determine threshold values of Gliomas grading.

Results: Mean maximum rCBV were 2.71±1.41 for low grades (I & II), and 8.14±2.58 for high grades (III & IV) Gliomas (p=0.001). Mean minimum ADC were 1.47±.46 ×103 mm2/s for low grades (I & II), and .47±.38×103 mm2/s for high grades (III & IV) Gliomas (p=0.001). We can get 0.94×103 mm2/s for minimum ADC and 3.85 for maximum rCBV as a difference cutoff point between low and high-grade Gliomas.

Conclusion: Combination of both DWI and PWI techniques, with measurement of minimum ADC and maximum rCBV can be used to distinguish between high grade and low-grade Glioma tumors.

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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1394/12/16 | پذیرش: 1394/12/16 | انتشار: 1394/12/16