Volume 1, Issue 1 (Spring 2015)                   Caspian.J.Neurol.Sci 2015, 1(1): 27-34 | Back to browse issues page


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Gomar A, Hosseini A, Mirazi N, Gomar M. Effect of Hydroethanolic Extract of Rubus fruticosus on Neuropathic Pain in Wistar Diabetic Rats. Caspian.J.Neurol.Sci. 2015; 1 (1) :27-34
URL: http://cjns.gums.ac.ir/article-1-33-en.html
1- Department of Biology, Science & Research Institute, Islamic Azad University, Tehran, Iran ; gomar.ucla@yahoo.com
2- Department of Physiology, Faculty of Biological Science, Shahid Beheshti University, Tehran, Iran
3- Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamadan, Iran
4- Student of Surgical technology, Faculty of Para medicine, Aja University of Medical Sciences, Tehran, Iran
Abstract:   (3197 Views)

Background: Diabetes mellitus is the most common metabolic disorder with many complications such as neuropathic pain which relief from it is a dilemma. Objectives: To investigate the effect of hydroethanolic extract of Rubus fruticosus on neuropathic pain in diabetic rats. Materials and Methods: In this experimental case –control study, forty eight male Wistar rats (250±20 g) were divided randomly to non-diabetic and diabetic groups. Streptozotocin (60 mg/kg, intra-peritoneal) was used to induce experimental diabetes. Each group was divided into three groups: receiving orally normal saline, 100 and 200 mg/kg doses of Rubus fruticosus extract for 30 days. At the end the rats were subjected to Tail-Flick test. The data were analyzed by one-way and two-way ANOVA followed by Tukey’s test in SPSS 21. Results: In a paired comparison, all diabetic groups had shorter latency of tail-flicking time (p < 0.01) and lower pain tolerance threshold. Also among diabetic rats, significant differences existed between saline group and group receiving the extract at a dose of 100 mg/Kg (p < 0.01), between saline group and the group receiving the extract at a dose of 200 mg/Kg (p < 0.001) and also between the groups receiving extract at two different doses (p < 0.001). But, only diabetic group receiving the extract at a dose of 200 mg/Kg showed positive significant difference with non-diabetic control group (p < 0.01). Conclusions: The hydroethanolic extract of Rubus fruticosus can heighten the pain tolerance threshold and reduce the neuropathic pain induced by diabetes mellitus.

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Type of Study: Research | Subject: Special
Received: 2015/03/21 | Accepted: 2015/03/21 | Published: 2015/03/21

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