دوره 4، شماره 14 - ( 5-1397 )                   جلد 4 شماره 14 صفحات 108-113 | برگشت به فهرست نسخه ها


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Sedighi B, Ghaseminejad A, Abna Z, Hassani B. Optical Coherence Tomography and Corpus Callosum Index in Cognitive Assessment of Multiple Sclerosis Patients. Caspian.J.Neurol.Sci. 2018; 4 (14) :108-113
URL: http://cjns.gums.ac.ir/article-1-220-fa.html
Optical Coherence Tomography and Corpus Callosum Index in Cognitive Assessment of Multiple Sclerosis Patients. مجله علوم اعصاب کاسپین. 1397; 4 (14) :108-113

URL: http://cjns.gums.ac.ir/article-1-220-fa.html


چکیده:   (222 مشاهده)
Background: Multiple Sclerosis (MS) is a neurodegenerative disease of central nervous system. Different approaches have been developed to study MS progression and cognitive dysfunction as the major symptom of the disease. The current study compared Optical Coherence Tomography (OCT) and Corpus Callosum Index (CCI) for the early evaluation of cognitive dysfunction in MS patients. 
Objectives: The aim of this study is compare OCT with corpus callosum index (CCI) in early evaluation of cognitive dysfunction in MS patients.
Materials & Methods: In this study, a total number of 30 patients with relapsing-remitting MS referring to outpatient clinic of Shafa Hospital (Kerman, Iran) were selected in 2016. CCI was assessed by MRI. The cognitive function of MS patients was evaluated by brief international cognitive assessment for MS and retinal nerve fiber layer thickness was measured by OCT. The obtained data were analyzed using SPSS, and the Chi-square test was used to compare the categorical variables.
Results: In this study on MS patients of both sexes and different ages, there was no significant correlation between cognitive status and CCI (P=0.804). Among the group with impaired cognition, 81.8% of patients had abnormal OCT, and only 2 patients had normal OCT. Furthermore, our data showed a significant correlation between OCT and cognition (P=0.026). 
Conclusion: According to this study, OCT is as useful method in the evaluation of axonal loss and predicting cognitive dysfunction in MS patients, compared to CCI or other measures.
متن کامل [PDF 1437 kb]   (150 دریافت)    
نوع مطالعه: كاربردي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۶/۹/۱۹ | پذیرش: ۱۳۹۷/۱/۱۲ | انتشار: ۱۳۹۷/۴/۱۰

فهرست منابع
1. Fjeldstad C, Bemben M, Pardo G. Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no history of optic neuritis identified by the use of spectral domain high-definition optical coherence tomography. J Clin Neurosci. 2011; 18(11):1469-72. [DOI:10.1016/j.jocn.2011.04.008] [PMID] [DOI:10.1016/j.jocn.2011.04.008]
2. Frohman EM, Fujimoto JG, Frohman TC, Calabresi PA, Cutter G, Balcer LJ. Optical coherence tomography: A window into the mechanisms of multiple sclerosis. Natl Clin Pract Neurol. 2008; 4(12):664-75. [DOI:10.1038/ncpneuro0950] [PMID] [PMCID] [DOI:10.1038/ncpneuro0950]
3. Wallin MT, Wilken JA, Kane R. Cognitive dysfunction in multiple sclerosis: Assessment, imaging, and risk factors. J Rehabil Res Dev. 2006; 43(1):63-72. [DOI:10.1682/JRRD.2004.09.0120] [PMID] [DOI:10.1682/JRRD.2004.09.0120]
4. Sartori E, Edan G. Assessment of cognitive dysfunction in multiple sclerosis. J Neurol Sci. 2006; 245(1-2):169-75. [DOI:10.1016/j.jns.2005.07.016] [PMID] [DOI:10.1016/j.jns.2005.07.016]
5. Achiron A, Barak Y. Cognitive changes in early MS: A call for a common framework. J Neurol Sci. 2006; 245(1-2):47-51. [DOI:10.1016/j.jns.2005.05.019] [DOI:10.1016/j.jns.2005.05.019]
6. Guenter W, Jablonska J, Bielinski M, Borkowska A. Neuroimaging and genetic correlates of cognitive dysfunction in multiple sclerosis. Psychiatr Pol J. 2015; 49(5):897-910. [DOI:10.12740/PP/32182] [PMID] [DOI:10.12740/PP/32182]
7. Dobryakova E, Wylie GR, DeLuca J, Chiaravalloti ND. A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial. Brain Imaging Behav. 2014; 8(3):403-6. [DOI:10.1007/s11682-014-9309-9] [PMID] [PMCID] [DOI:10.1007/s11682-014-9309-9]
8. Rocca MA, Valsasina P, Hulst HE, Abdel-Aziz K, Enzinger C, Gallo A, et al. Functional correlates of cognitive dysfunction in multiple sclerosis: A multicenter fMRI Study. Hum Brain Mapp. 2014; 35(12):5799-814. [DOI:10.1002/hbm.22586] [PMID] [DOI:10.1002/hbm.22586]
9. Wojtowicz MA, Ishigami Y, Mazerolle EL, Fisk JD. Stability of intraindividual variability as a marker of neurologic dysfunction in relapsing remitting multiple sclerosis. J Clin Exp Neuropsychol. 2014; 36(5):455-63. [DOI:10.1080/13803395.2014.903898] [PMID] [DOI:10.1080/13803395.2014.903898]
10. Yaldizli O, Atefy R, Gass A, Sturm D, Glassl S, Tettenborn B, et al. Corpus Callosum Index and long-term disability in multiple sclerosis patients. J Neurol. 2010; 257(8):1256-64. [DOI:10.1007/s00415-010-5503-x] [PMID] [DOI:10.1007/s00415-010-5503-x]
11. Rimkus Cde M, Junqueira Tde F, Lyra KP, Jackowski MP, Machado MA, Miotto EC, et al. Corpus callosum microstructural changes correlate with cognitive dysfunction in early stages of relapsing-remitting multiple sclerosis: Axial and radial diffusivities approach. Mult Scler Int. 2011; 2011:1-7. [DOI:10.1155/2011/304875] [DOI:10.1155/2011/304875]
12. Ozturk A, Smith SA, Gordon-Lipkin EM, Harrison DM, Shiee N, Pham DL, et al. MRI of the corpus callosum in multiple sclerosis: association with disability. Mult Scler J Exp Transl Clin. 2010; 16(2):166-77. [DOI:10.1177/1352458509353649] [PMID] [PMCID] [DOI:10.1177/1352458509353649]
13. Fisher JB, Jacobs DA, Markowitz CE, Galetta SL, Volpe NJ, Nano-Schiavi ML, et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmol J. 2006; 113(2):324-32. [DOI:10.1016/j.ophtha.2005.10.040] [PMID] [DOI:10.1016/j.ophtha.2005.10.040]
14. Yeh EA, Weinstock-Guttman B, Lincoff N, Reynolds J, Weinstock A, Madurai N, et al. Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset. Mult Scler J. 2009; 15(7):802-10. [DOI:10.1177/1352458509104586] [PMID] [DOI:10.1177/1352458509104586]
15. Toledo J, Sepulcre J, Salinas-Alaman A, Garcia-Layana A, Murie-Fernandez M, Bejarano B, et al. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler J. 2008; 14(7):906-12. [DOI:10.1177/1352458508090221] [PMID] [DOI:10.1177/1352458508090221]
16. Figueira FF, Santos VS, Figueira GM, Silva AC. Corpus Callosum Index: A practical method for long-term follow-up in multiple sclerosis. Arq Neuropsiquiatr. 2007; 65(4a):931-5. [DOI:10.1590/S0004-282X2007000600001] [PMID] [DOI:10.1590/S0004-282X2007000600001]
17. Mohammadi MR, Zhand P, Mortazavi Moghadam B, Golalipour MJ. Measurement of the corpus callosum using magnetic resonance imaging in the north of iran. Iran J Radiol. 2011; 8(4):218-23. [DOI:10.5812/iranjradiol.4495] [PMID] [PMCID] [DOI:10.5812/iranjradiol.4495]
18. Sedighi B, Shafa MA, Abna Z, Ghaseminejad AK, Farahat R, Nakhaee N, et al. Association of cognitive deficits with optical coherence tomography changes in multiple sclerosis patients. J Mult Scler. 2013; 1(2):117. [DOI:10.4172/jmso] [DOI:10.4172/jmso]
19. Benedict RH, Amato MP, Boringa J, Brochet B, Foley F, Fredrikson S, et al. Brief International Cognitive Assessment for MS (BICAMS): International standards for validation. BMC Neurol J. 2012; 12:55. [DOI:10.1186/1471-2377-12-55] [PMID] [PMCID] [DOI:10.1186/1471-2377-12-55]
20. Parisi V, Manni G, Spadaro M, Colacino G, Restuccia R, Marchi S, et al. Correlation between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophthalmol Vis Sci. 1999; 40(11):2520-7. [PMID] [PMID]
21. Petzold A, de Boer JF, Schippling S, Vermersch P, Kardon R, Green A, et al. Optical coherence tomography in multiple sclerosis: A systematic review and meta-analysis. Lancet Neurol. 2010; 9(9):921-32. [DOI:10.1016/S1474-4422(10)70168] [DOI:10.1016/S1474-4422(10)70168-X]
22. Granberg T, Martola J, Bergendal G, Shams S, Damangir S, Aspelin P, et al. Corpus callosum atrophy is strongly associated with cognitive impairment in multiple sclerosis: Results of a 17-year longitudinal study. Mult Scler J. 2015; 21(9):1151-8. [DOI:10.1177/1352458514560928] [PMID] [DOI:10.1177/1352458514560928]

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