دوره 4، شماره 12 - ( 10-1396 )                   جلد 4 شماره 12 صفحات 1-5 | برگشت به فهرست نسخه ها

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Mohammadianinejad S, Majidinasab N, Nejati A, Hatamian H, Mehramiri A, Sajedi S et al . Tapering Oral Steroid Treatment After IV Methylprednisolone Pulse Therapy in Demyelinating Optic Neuritis. Caspian.J.Neurol.Sci. 2018; 4 (12) :1-5
URL: http://cjns.gums.ac.ir/article-1-212-fa.html
Tapering Oral Steroid Treatment After IV Methylprednisolone Pulse Therapy in Demyelinating Optic Neuritis. مجله علوم اعصاب کاسپین. 1396; 4 (12) :1-5

URL: http://cjns.gums.ac.ir/article-1-212-fa.html


چکیده:   (336 مشاهده)
Background: Optic neuritis is an inflammation of the optic nerve. Because of importance of vision for human, management of optic neuritis is an important issue in neurology.
Objectives: This study aimed at assessing the effect of oral steroid treatment after intravenous (IV) methylprednisolone therapy on demyelinating optic neuritis.
Materials & Methods: 60 Patients with first episode of acute demyelinating optic neuritis who referred to a neurology clinic in an academic hospital in south-west of Iran in 2015-2016 included in this randomized double-blind clinical trial study (No: IRCT2015102724735N1). They were divided into two groups with (A) and without (B) tapering oral steroid treatment after IV methylprednisolone. Visual acuity and color vision were measured before treatment, before oral tapering, 1 and 3 months after treatment. Independent t-test in SPSS software version 20 was used to analyze the data. P<0.05 was considered as the level of significance.
Results: Visual acuity in two groups did not have any significant difference in any time point of assessment (P>0.05).Frequency of color vision abnormality in groups A and B were at baseline (53.3% vs. 56.6%) (P=0.796), before oral tapering (43.3% vs. 30%, P=0.284), 1 month after treatment (23.3% vs. 30%, P=0.559), 3 months after treatment (0% vs. 23%, P=0.011). 
Conclusion: Oral steroid treatment after IV methylprednisolone pulse therapy improves color vision after 3 months in patients with demyelinating optic neuritis but has no effect on visual acuity.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۶/۱۲/۵ | پذیرش: ۱۳۹۶/۱۲/۵ | انتشار: ۱۳۹۶/۱۲/۵

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