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:: دوره 3، شماره 11 - ( 7-1396 ) ::
جلد 3 شماره 11 صفحات 231-240 برگشت به فهرست نسخه ها
Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
چکیده:   (25 مشاهده)
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders.
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نوع مطالعه: مروری | موضوع مقاله: تخصصي
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Etemadifar M, Fazli A. Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders. Caspian.J.Neurol.Sci. 2017; 3 (11) :231-240
URL: http://cjns.gums.ac.ir/article-1-206-fa.html
Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders. مجله علوم اعصاب کاسپین. 1396; 3 (11) :231-240

URL: http://cjns.gums.ac.ir/article-1-206-fa.html

دوره 3، شماره 11 - ( 7-1396 ) برگشت به فهرست نسخه ها
مجله علوم اعصاب کاسپین Caspian Journal of Neurological Sciences

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