دوره 3، شماره 11 - ( 7-1396 )                   جلد 3 شماره 11 صفحات 231-240 | برگشت به فهرست نسخه ها


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Etemadifar M, Fazli A. Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders. Caspian.J.Neurol.Sci. 2017; 3 (11) :231-240
URL: http://cjns.gums.ac.ir/article-1-206-fa.html
Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders. مجله علوم اعصاب کاسپین. 1396; 3 (11) :231-240

URL: http://cjns.gums.ac.ir/article-1-206-fa.html


چکیده:   (631 مشاهده)
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders.
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نوع مطالعه: مروری | موضوع مقاله: تخصصي
دریافت: ۱۳۹۶/۹/۹ | پذیرش: ۱۳۹۶/۹/۹ | انتشار: ۱۳۹۶/۹/۹

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