Volume 3, Issue 11 (Autumn 2017)                   Caspian.J.Neurol.Sci 2017, 3(11): 206-213 | Back to browse issues page


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1- Department of Neurology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; hashemyi@mums.ac.ir
Abstract:   (716 Views)
Background: Among different mechanisms, oxidative stress has a possible role in neural injury in cerebrovascular events.
Objectives: Assessment the oxidants-antioxidants imbalance in ischemic and hemorrhagic strokes.
Materials and Methods: Serum level of malondialdehyde, the main marker of lipid peroxidation, and total antioxidant capacity were measured in a group of 48 stroke patients consisting of 24 ischemic and 24 hemorrhagic cases with confirmed diagnosis by brain CT scan. Lesion volume and modified National Institutes of Health Stroke Scale (NIHSS) in ischemic stroke, as well as location and volume of hematoma in hemorrhagic stroke based on the first brain CT scan were determined as study variables.
Results: These two major groups did not have different oxidative profile. Low levels of total antioxidant capacity and high levels of malondialdehyde were associated with higher lesion volume in hemorrhagic stroke patients.
Conclusions: This data suggested that oxidative stress is associated with lesion volume and therefore severity of hemorrhagic stroke.
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Type of Study: Research | Subject: Special
Received: 2017/11/23 | Accepted: 2017/11/23 | Published: 2017/11/23

References
1. Rodrigo R, Fernández-Gajardo R, Gutiérrez R, Matamala JM, Carrasco R, Miranda-Merchak A, et al. Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities. CNS Neurol Disord Drug Targets 2013;12(5):698-714. [DOI:10.2174/1871527311312050015] [PMID]
2. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al. American Heart Association. Heart Disease and Stroke Statistics. 2011 update. Circulation 2011; 123(4):e18-e209. [DOI:10.1161/CIR.0b013e3182009701] [PMID] [PMCID]
3. Cherubini A, Polidori MC, Bregnocchi M, Pezzuto S, Cecchetti R, Ingegni T. Antioxidant Profile and Early Outcome in Stroke Patients. Stroke 2000; 31(10):2295-300. [DOI:10.1161/01.STR.31.10.2295] [PMID]
4. Andersen KK, Olsen TS, Dehlendorff C, Kammersgaard LP. Hemorrhagic and Ischemic Strokes Compared: Stroke Severity, Mortality, and Risk Factors. Stroke 2009; 40(6):2068-72. [DOI:10.1161/STROKEAHA.108.540112] [PMID]
5. Pradeep H, Diya JB, Shashikumar S, Rajanikant GK. Oxidative Stress – assassin behind the Ischemic Stroke. Folia Neuropathol 2012;50(3):219-30. [DOI:10.5114/fn.2012.30522] [PMID]
6. Yang TH, Chang CY, Hu ML. Various Forms of Homocysteine and Oxidative Status in the Plasma of Ischemic-Stroke Patients as Compared to Healthy Controls. Clin Biochem 2004;37(6):494-9. [DOI:10.1016/j.clinbiochem.2004.02.006] [PMID]
7. Spranger M, Krempien S, Schwab S, Donneberg S, Hacke W. Superoxide Dismutase Activity in Serum of Patients with Acute Cerebral Ischemic Injury. Stroke 1997; 28(12):2425-8. [DOI:10.1161/01.STR.28.12.2425] [PMID]
8. Loh KP, Huang SH, De Silva R, Tan BK, Zhu YZ. Oxidative Stress: Apoptosis in Neuronal injury. Curr Alzheimer Res 2006;3(4):327-37. [DOI:10.2174/156720506778249515] [PMID]
9. Facchinetti F, Dawson VL, Dawson TM. Free Radicals as Mediators of Neuronal Injury. Cell Mol Neurobiol 1998;18(6):667-82. [DOI:10.1023/A:1020221919154] [PMID]
10. Shi H, Liu KJ. Cerebral Tissue Oxygenation and Oxidative Brain Injury During Ischemia and Reperfusion. Front Biosci 2007;12:1318-28. [DOI:10.2741/2150] [PMID]
11. Rehncrona S, Mela L, Siesjo BK. Recovery of Brain Mitochondrial Function in the Rat After Complete Cerebral Ischaemia. Stroke 1979;10(4): 437-46. [DOI:10.1161/01.STR.10.4.437] [PMID]
12. Kaur J, Sarika A, Bhawna S, Thakur LC, Gambhir J, Prabhu KM. Role of Oxidative Stress in Pathophysiology of Transient Ischemic Attack and Stroke. Int J Biol Med Res 2011;2(3):611-5.
13. Aygul R, Demircan B, Erdem F, Ulvi H, Yildirim A, Demirbas F. Plasma Values of Oxidants and Antioxidants in Acute Brain Hemorrhage. Biol Trace Elem Res 2005; 108(1-3):43-52. [DOI:10.1385/BTER:108:1-3:043]
14. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, Terry E, et al. Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study. Stroke 2008;39(1):100-4. [DOI:10.1161/STROKEAHA.107.488189] [PMID]
15. Domínguez C, Delgado P, Vilches A, Martín-Gallán P, Ribó M, Santamarina E, et al. Oxidative Stress After Thrombolysis-induced Reperfusion in Human Stroke. Stroke 2010;41(4):653-60. [DOI:10.1161/STROKEAHA.109.571935] [PMID]
16. Cano CP, Bermúdez VP, Atencio HE, Medina MT, Anilsa A, Souki A, et al. Increased Serum Malondialdehyde and Decreased Nitric Oxide within 24 hours of Thrombotic Stroke Onset. Am J Ther 2003;10(6):473-6. [DOI:10.1097/00045391-200311000-00018] [PMID]
17. Seet RC, Lee CY, Chan BP, Sharma VK, Teoh HL, Venketasubramanian N, et al. Oxidative Damage in Ischemic Stroke Revealed Using Multiple Biomarkers. Stroke 2011;42(8):2326-9. [DOI:10.1161/STROKEAHA.111.618835] [PMID]
18. Ullegaddi R, Powers HJ, Gariballa SE. Antioxidant Supplementation with or Without Bgroup Vitamins After Acute Ischemic Stroke: a Randomized Controlled Trial. JPEN J Parenter Enteral Nutr 2006;30(2):108-14. [DOI:10.1177/0148607106030002108] [PMID]
19. Polidori MC, Praticó D, Ingegni T, Mariani E, Spazzafumo L, Del Sindaco P, et al. Effects of Vitamin C and Aspirin in Ischemic Stroke-related Lipid Peroxidation: Results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study. Biofactors 2005; 24(1-4):265-74. [DOI:10.1002/biof.5520240131] [PMID]
20. Asplund K. Antioxidant Vitamins in the Prevention of Cardiovascular Disease: a Systematic Review. J Int Med 2002; 251(5):372-92. [DOI:10.1046/j.1365-2796.2002.00973.x] [PMID]
21. Valenzuela A. The Biological Significance of Malondialdehyde Determination in Assessment of Tissue Oxidative Stress. Life Sci 1991;48(4):301-9. [DOI:10.1016/0024-3205(91)90550-U]
22. Appelros P, Terént A. Characteristics of the NIHSS results: Results from a Population-based Stroke Cohort at Baseline and After One Year. Cerebrovasc Dis 2004; 17(1):21-7. [DOI:10.1159/000073894] [PMID]
23. Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M. The ABCs of Measuring Intracerebral Hemorrhage Volumes. Stroke 1996;27(8):1304-5. [DOI:10.1161/01.STR.27.8.1304] [PMID]
24. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A. A Novel Method for Measuring Antioxidant Capacity and Its Application to Monitoring the Antioxidant Status in Premature Neonates. Clin Sci (Lond) 1993; 84(4):407-12. [DOI:10.1042/cs0840407]
25. Miller NJ, Rice-Evans CA. Factors Influencing the Antioxidant Activity Determined by the ABTS.+ Radical Cation Assay. Free Radic Res 1997; 26(3):195-9. [DOI:10.3109/10715769709097799] [PMID]
26. Armstrong D, Browne R. The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Enzymes and Compounds to Oxidative Stress as Applied to the Clinical Chemistry Laboratory. Adv Exp Med Biol 1994;366:43-58. _4 [DOI:10.1007/978-1-4615-1833-4] [PMID]
27. Allen CL, Bayraktutan U. Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke. Int J Stroke 2009;4(6):461-70. [DOI:10.1111/j.1747-4949.2009.00387.x] [PMID]
28. Santos MT, Valles J, Aznar J, Vilches J. Determination of plasma malondialdehyde like material and its clinical application in stroke patients. J Clin Pathol. 1980;33(10):973-6. [DOI:10.1136/jcp.33.10.973] [PMID] [PMCID]
29. Srikrishna R, Suresh DR. Biochemical Study of Antioxidant Profile in Acute Ischemic Stroke. Stroke BJMP 2009;2(1):35-7.
30. Zimmermann C, Winnefeld K, Streck S, Roskos M, Haberl RL. Antioxidant Status in Acute Stroke Patients and Patients at Stroke Risk. Eur Neurol 2004; 51(3):157-61. [DOI:10.1159/000077662] [PMID]
31. Leinonen JS, Ahonen JP, Lönnrot K, Jehkonen M, Dastidar P, Molnár G, et al. Low Plasma Antioxidant Activity Is Associated with High Lesion Volume and Neurological Impairment in Stroke. Stroke 2000;31(1):33-9. [DOI:10.1161/01.STR.31.1.33] [PMID]
32. Gonullu H, Aslan M, Karadas S, Kati C, Duran L, Milanlioglu A, et al. Serum Prolidase Enzyme Activity and Oxidative Stress levels in Patients with Acute Hemorrhagic Stroke. Scand J Clin Lab Invest 2014 74(3):199-205. [DOI:10.3109/00365513.2013.873949] [PMID]