[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 2, Issue 4 (Winter 2016) ::
Caspian.J.Neurol.Sci 2016, 2(4): 42-53 Back to browse issues page
Grading of Glioma Tumors by Analysis of Minimum Apparent Diffusion Coefficient and Maximum Relative Cerebral Blood Volume
Mahdiyeh Saberi , Fariborz Faeghi , Hossein Ghanaati , Mojtaba Miri , Ayoob Rostamzadeh , Soheila Khodakarim , Farhad Naleini
Medical Physicist, Assistant Professor of Medical Imaging, Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; f_faeghi@sbmu.ac.ir
Abstract:   (2245 Views)

Background: Gliomas are the most common primary neoplasms of the central nervous system. Relative cerebral blood volume (rCBV) could estimate high-grade Gliomas computed with dynamic susceptibility contrast MR imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier.

Objectives: Our intent was to clarify the usefulness of diffusion-weighted magnetic resonance imaging (DWI) and perfusion weighted magnetic resonance imaging (PWI) in the grading of Gliomas.

Materials and Methods: Both PWI and DWI with a three-tesla scanner investigated nineteen consecutive patients with Gliomas. The means of rCBV and ADC values have been compared among the tumor groups with t-test and ROC curve analysis to determine threshold values of Gliomas grading.

Results: Mean maximum rCBV were 2.71±1.41 for low grades (I & II), and 8.14±2.58 for high grades (III & IV) Gliomas (p=0.001). Mean minimum ADC were 1.47±.46 ×103 mm2/s for low grades (I & II), and .47±.38×103 mm2/s for high grades (III & IV) Gliomas (p=0.001). We can get 0.94×103 mm2/s for minimum ADC and 3.85 for maximum rCBV as a difference cutoff point between low and high-grade Gliomas.

Conclusion: Combination of both DWI and PWI techniques, with measurement of minimum ADC and maximum rCBV can be used to distinguish between high grade and low-grade Glioma tumors.

Keywords: Diffusion Magnetic Resonance Imaging, Neoplasm Grading
Full-Text [PDF 605 kb]   (1214 Downloads) |   |   Full-Text (HTML)  (212 Views)  
Type of Study: Research | Subject: Special
Add your comments about this article
Your username or Email:

Write the security code in the box >

DOI: 10.18869/acadpub.cjns.2.4.42

XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Saberi M, Faeghi F, Ghanaati H, Miri M, Rostamzadeh A, Khodakarim S et al . Grading of Glioma Tumors by Analysis of Minimum Apparent Diffusion Coefficient and Maximum Relative Cerebral Blood Volume. Caspian.J.Neurol.Sci. 2016; 2 (4) :42-53
URL: http://cjns.gums.ac.ir/article-1-85-en.html
Volume 2, Issue 4 (Winter 2016) Back to browse issues page
مجله علوم اعصاب کاسپین Caspian Journal of Neurological Sciences

   The journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Persian site map - English site map - Created in 0.905 seconds with 833 queries by yektaweb 3567