Volume 2, Issue 4 (Winter 2016)                   Caspian.J.Neurol.Sci 2016, 2(4): 42-53 | Back to browse issues page


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Saberi M, Faeghi F, Ghanaati H, Miri M, Rostamzadeh A, Khodakarim S et al . Grading of Glioma Tumors by Analysis of Minimum Apparent Diffusion Coefficient and Maximum Relative Cerebral Blood Volume. Caspian.J.Neurol.Sci. 2016; 2 (4) :42-53
URL: http://cjns.gums.ac.ir/article-1-85-en.html
1- Medical Imaging Physicist, Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Medical Physicist, Assistant Professor of Medical Imaging, Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; f_faeghi@sbmu.ac.ir
3- Radiologist, Advanced diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
4- Neurosurgen, Department of Neurosurgery, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
5- Neuroscientist, Funding Member of Iranian Society of Cellular and Molecular Imaging, Department of Anatomy and Neuroscience, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
6- Epidemiologist, Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7- Radiologist, Emam Reza Hospital, Faculty of Medicine, Krmanshah University of Medical Sciences, Krmanshah, Iran
Abstract:   (2752 Views)

Background: Gliomas are the most common primary neoplasms of the central nervous system. Relative cerebral blood volume (rCBV) could estimate high-grade Gliomas computed with dynamic susceptibility contrast MR imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier.

Objectives: Our intent was to clarify the usefulness of diffusion-weighted magnetic resonance imaging (DWI) and perfusion weighted magnetic resonance imaging (PWI) in the grading of Gliomas.

Materials and Methods: Both PWI and DWI with a three-tesla scanner investigated nineteen consecutive patients with Gliomas. The means of rCBV and ADC values have been compared among the tumor groups with t-test and ROC curve analysis to determine threshold values of Gliomas grading.

Results: Mean maximum rCBV were 2.71±1.41 for low grades (I & II), and 8.14±2.58 for high grades (III & IV) Gliomas (p=0.001). Mean minimum ADC were 1.47±.46 ×103 mm2/s for low grades (I & II), and .47±.38×103 mm2/s for high grades (III & IV) Gliomas (p=0.001). We can get 0.94×103 mm2/s for minimum ADC and 3.85 for maximum rCBV as a difference cutoff point between low and high-grade Gliomas.

Conclusion: Combination of both DWI and PWI techniques, with measurement of minimum ADC and maximum rCBV can be used to distinguish between high grade and low-grade Glioma tumors.

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Type of Study: Research | Subject: Special
Received: 2016/03/6 | Accepted: 2016/03/6 | Published: 2016/03/6

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