Volume 2, Issue 4 (Winter 2016)                   Caspian.J.Neurol.Sci 2016, 2(4): 29-35 | Back to browse issues page


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Seyyedmajidi M, Banikarim S, Ardalan A, Hozhabrossadati S, Norouzi A, Vafaeimanesh J. Helicobacter pylori and Migraine: Is Eradication of Helicobacter pylori Effective in Relief of Migraine Headache?. Caspian.J.Neurol.Sci. 2016; 2 (4) :29-35
URL: http://cjns.gums.ac.ir/article-1-83-en.html
1- Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
2- Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran ; j.vafaeemanesh@muq.ac.ir
Abstract:   (3033 Views)

Background: Association between Helicobacter pylori (HP) infection and migraine and the effect of HP eradication on relief of migraine headache have been studied but the results are controversial.

Objectives: To evaluate the effect of HP eradication in treatment of patients affected by migraine.

Materials and Methods: Eighty consecutive HP infected patients affected by migraine without aura were enrolled in this clinical trial. They have referred to an endoscopy clinic for work-up of HP infection from October 2013 to November 2014. Patients were randomly assigned in 2 groups using 2 different regimens; Group A: migraine treatment and a 14-day triple therapy for HP infection and Group B: migraine treatment without HP eradication. The mean duration (hour), headache severity (MIDAS) and the frequency (per month) of clinical headache attacks were calculated upon enrollment in the study and at 6 months and 12 months after treatment. All data were analyzed using SPSS version 16. Comparison of categorical variables across the groups was performed using Chi-square test.

Results: In group A, HP infection was eradicated in 34 of 40 patients (85%). After treatment in eradicated patients compared with the control group there was significant decrease in severity and frequency (but not in duration) of the migraine attacks at 6 months (p<0.001) and significant decrease in intensity, frequency and duration of the migraine attacks at 12 months (p<0.001).

Conclusion: HP should be considered and examined in migranous patients and eradication treatment can be beneficial for relief of clinical attacks.

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Type of Study: Research | Subject: Special
Received: 2016/03/6 | Accepted: 2016/03/6 | Published: 2016/03/6

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