Volume 7, Issue 1 (Winter 2021)                   Caspian.J.Neurol.Sci 2021, 7(1): 10-16 | Back to browse issues page

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Shaygannejad V, Barzegar M, Manouchehri N, Esmaeil N, Nehzat N, Badihian S, et al . Anti-myelin Oligodendrocyte Glycoprotein in Aquaporin-4 Negative Neuromyelitis Optica Spectrum Disorder. Caspian.J.Neurol.Sci. 2021; 7 (1) :10-16
URL: http://cjns.gums.ac.ir/article-1-383-en.html
1- Department of Neurology, Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2- Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (131 Views)
Background: The absence of Aquaporin-4 Antibody (AQP4-Ab) in a fraction of the Neuromyelitis
Optica Spectrum Disorder (NMOSD) patients has led to a search for other serologic markers. Myelin
Oligodendrocyte Glycoprotein (MOG) is a protein component of the myelin sheets encapsulating
the neural fibers.
Objectives: We aimed to compare the presence and levels of anti-MOG (Ig-G) in a group of seronegative
NMOSD patients with a healthy control group.
Materials & Methods: In this cross-sectional study, 30 NMOSD patients with negative AQP-Ab
status, who were referred to the Neurology Clinic of Kashani University Hospital in Isfahan City,
Iran, from March 2015 to March 2016, and 26 healthy controls were consecutively recruited. Their
baseline demographic and clinical data were recorded. Serum anti-MOG levels were measured in
both groups. The obtained data were analyzed using the Student t-test, Mann-Whitney U, and Chisquare
test in SPSS V. 18.
Results: The anti-MOG test results were statistically higher in patients (n=12, 37.5%) compared
to controls (n=0, 0%) (P<0.0001). The level of anti-MOG in Healthy Control (HC) was higher
compared to patients with negative anti-MOG (P<0.0001) and was lower than patients with positive
anti-MOG (P<0.0001).
Conclusion: Our study showed that nearly one-third of seronegative NMOSD patients were positive
for MOG-Ab. Further studies are needed to assess the characteristics and outcome of these patients.
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Type of Study: Research | Subject: Special
Received: 2021/03/14 | Accepted: 2021/01/21 | Published: 2021/01/21

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