Volume 3, Issue 11 (Autumn 2017)                   Caspian.J.Neurol.Sci 2017, 3(11): 231-240 | Back to browse issues page


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Etemadifar M, Fazli A. Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders. Caspian.J.Neurol.Sci. 2017; 3 (11) :231-240
URL: http://cjns.gums.ac.ir/article-1-206-en.html
1- Professor of Neurology, Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran
2- Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran; ali96fazli@yahoo.com
Abstract:   (174 Views)
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders.
Full-Text [PDF 448 kb]   (54 Downloads)    
Type of Study: Review | Subject: Special
Received: 2017/11/30 | Accepted: 2017/11/30 | Published: 2017/11/30

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