Volume 3, Issue 8 (Winter 2017)                   Caspian.J.Neurol.Sci 2017, 3(8): 46-53 | Back to browse issues page


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Lyman D. B cell Therapy to Treat an Axonal Neuropathy in Mixed Connective Tissue Disease . Caspian.J.Neurol.Sci. 2017; 3 (8) :46-53
URL: http://cjns.gums.ac.ir/article-1-154-en.html
MPH retired, Department of Family Medicine, University of Tennessee, Jackson, Tennessee; dlymanmdmph@gmail.com
Abstract:   (584 Views)

The B cell is a vital contributor to humoral immunity. The B cell-specific antigen CD20 is expressed during B cell development, starting at the pre-B cell level and persists through B cell differentiation, but is lost during terminal differentiation to plasma cells.

Rituximab is a monoclonal antibody that destroys both normal and malignant B cells that have CD20 on their surfaces and is therefore used to treat diseases characterized by excessive B cells, overactive B cells, or dysfunctional B cells.

The connective tissue diseases and vasculitis mediated by B cell may cause various disorders of the peripheral nervous system especially axonal neuropathy. B cell–directed therapies may represent a promising new treatment for autoimmune axonal neuropathies.

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Type of Study: Review | Subject: Special
Received: 2017/04/13 | Accepted: 2017/04/13 | Published: 2017/04/13

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