Volume 2, Issue 6 (Summer 2016)                   Caspian.J.Neurol.Sci 2016, 2(6): 33-38 | Back to browse issues page


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Roudbary S, Alizadeh A, Ghayeghran A, Roshan F. Serum Uric Acid as a Potential Concomitant with Carotid Atherosclerosis . Caspian.J.Neurol.Sci. 2016; 2 (6) :33-38
URL: http://cjns.gums.ac.ir/article-1-114-en.html
1- Associate Professor, Neurology Department of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
2- Associate Professor, Department of Radiology, Guilan University of Medical Sciences, Rasht, Iran; a_alizadeh@gums.ac.ir
3- Assistant Professor, Neurology Department of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
4- Resident of radiology, Department of Radiology, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (1937 Views)

Background: Common carotid intima-media thickness (CC-IMT) measured by ultrasonography as a non-invasive method is nowadays known as a marker for early atherosclerosis.

Objectives: Survey the relationship between serum uric acid and carotid intima-media thickness considering hypertension.

Materials and Methods: This study was designed as a comparative cross-sectional study in northern Iran in 2013–2014. The samples for uric acid level were taken from 90 patients. Data were collected through questionnaires and a non-invasive ultrasound technique was used to measure IMT. The analysis of data was done by one-way ANOVA and Tukey post hoc tests and logistic regression model using SPSS software version 21. The significance level was set as 0.05.

Results: Patients in the 3 groups were the same age and gender. The measured carotid intima-media thickness was significantly different among the groups (p=0.004). Using multivariate logistic regression and entering all variables, The intima-media thickness of the carotid in the group with hypertensive and hyperuricemia was significantly higher than that of the other research groups (p<0.05).

Conclusion: An association was found between serum uric acid level and increased thickness of carotid intima-media and hyperuricemia can be considered as a risk factor for atherosclerosis.

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Type of Study: Research | Subject: Special
Received: 2016/10/2 | Accepted: 2016/10/2 | Published: 2016/10/2

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